Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1221887..1222398 Replicon chromosome
Accession NZ_CP068073
Organism Staphylococcus condimenti strain FDAARGOS_1148

Toxin (Protein)


Gene name TsdT Uniprot ID A0A143PEZ9
Locus tag I6J05_RS06230 Protein ID WP_047132367.1
Coordinates 1221887..1222093 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag I6J05_RS06235 Protein ID WP_015900833.1
Coordinates 1222105..1222398 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J05_RS06210 1217858..1219069 + 1212 WP_047132370.1 rod shape-determining protein RodA -
I6J05_RS06215 1219149..1219289 - 141 WP_165380001.1 hypothetical protein -
I6J05_RS06220 1219365..1221566 - 2202 WP_047132369.1 heavy metal translocating P-type ATPase -
I6J05_RS06225 1221663..1221872 - 210 WP_047132368.1 copper ion binding protein -
I6J05_RS06230 1221887..1222093 - 207 WP_047132367.1 cation transporter Toxin
I6J05_RS06235 1222105..1222398 - 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6J05_RS06240 1222563..1224043 + 1481 Protein_1198 cardiolipin synthase -
I6J05_RS06245 1224068..1224715 + 648 WP_047132366.1 HD domain-containing protein -
I6J05_RS06250 1224806..1225318 - 513 WP_047132365.1 GNAT family N-acetyltransferase -
I6J05_RS06255 1225429..1226304 - 876 WP_047132364.1 membrane protein insertase YidC -
I6J05_RS06260 1226393..1227031 - 639 WP_047132363.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7815.73 Da        Isoelectric Point: 4.1353

>T186598 WP_047132367.1 NZ_CP068073:c1222093-1221887 [Staphylococcus condimenti]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVTAVQVDLDSNEIKISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T186598 NZ_CP089610:2206466-2206843 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT186598 WP_015900833.1 NZ_CP068073:c1222398-1222105 [Staphylococcus condimenti]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT186598 NZ_CP089610:2206885-2207334 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143PEZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References