Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1669734..1670254 Replicon chromosome
Accession NZ_CP068069
Organism Staphylococcus equorum strain FDAARGOS_1149

Toxin (Protein)


Gene name TsdT Uniprot ID A0A192F7F2
Locus tag I6J06_RS08245 Protein ID WP_031266142.1
Coordinates 1669734..1669946 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID J9GWP4
Locus tag I6J06_RS08250 Protein ID WP_002507096.1
Coordinates 1669961..1670254 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J06_RS08225 1665308..1666663 - 1356 WP_021339945.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
I6J06_RS08230 1666676..1667746 - 1071 WP_002507100.1 D-alanine--D-alanine ligase -
I6J06_RS08235 1668021..1669223 + 1203 WP_002507099.1 rod shape-determining protein RodA -
I6J06_RS08240 1669379..1669519 - 141 WP_002507098.1 hypothetical protein -
I6J06_RS08245 1669734..1669946 - 213 WP_031266142.1 heavy-metal-associated domain-containing protein Toxin
I6J06_RS08250 1669961..1670254 - 294 WP_002507096.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6J06_RS08255 1670398..1671882 + 1485 WP_021339943.1 cardiolipin synthase -
I6J06_RS08260 1672010..1672660 + 651 WP_021339942.1 HD domain-containing protein -
I6J06_RS08265 1672731..1673600 - 870 WP_002507093.1 membrane protein insertase YidC -
I6J06_RS08270 1673688..1674326 - 639 WP_021339941.1 thiamine phosphate synthase -
I6J06_RS08275 1674326..1675117 - 792 WP_031266140.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(18-67)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8116.13 Da        Isoelectric Point: 4.5086

>T186596 WP_031266142.1 NZ_CP068069:c1669946-1669734 [Staphylococcus equorum]
VVTKVIYISGIENETQQKHIEQQLKQLHGVHQVNIEIESNNGKIFIDFETPASLNNLEKEVYDLGYEILY

Download         Length: 213 bp

>T186596 NZ_CP089610:1966818-1967066 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11195.87 Da        Isoelectric Point: 6.4791

>AT186596 WP_002507096.1 NZ_CP068069:c1670254-1669961 [Staphylococcus equorum]
MAEIQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNGVATKLLDHHMKSCIMEKVEQGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT186596 NZ_CP089610:1966606-1966818 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192F7F2

Antitoxin

Source ID Structure
AlphaFold DB J9GWP4

References