Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1658255..1658784 Replicon chromosome
Accession NZ_CP068069
Organism Staphylococcus equorum strain FDAARGOS_1149

Toxin (Protein)


Gene name mazF Uniprot ID K7S376
Locus tag I6J06_RS08185 Protein ID WP_002511418.1
Coordinates 1658255..1658617 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID J9GY23
Locus tag I6J06_RS08190 Protein ID WP_002507108.1
Coordinates 1658614..1658784 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J06_RS08165 1655260..1656030 - 771 WP_002507114.1 RNA polymerase sigma factor SigB -
I6J06_RS08170 1656005..1656487 - 483 WP_002507113.1 anti-sigma B factor RsbW -
I6J06_RS08175 1656489..1656815 - 327 WP_002511417.1 anti-sigma factor antagonist -
I6J06_RS08180 1656895..1657896 - 1002 WP_002507111.1 PP2C family protein-serine/threonine phosphatase -
I6J06_RS08185 1658255..1658617 - 363 WP_002511418.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6J06_RS08190 1658614..1658784 - 171 WP_002507108.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I6J06_RS08195 1658872..1660020 - 1149 WP_021339950.1 alanine racemase -
I6J06_RS08200 1660144..1660494 - 351 WP_021339949.1 holo-ACP synthase -
I6J06_RS08205 1660527..1661063 - 537 WP_002507105.1 PH domain-containing protein -
I6J06_RS08210 1661056..1662561 - 1506 WP_021339948.1 PH domain-containing protein -
I6J06_RS08215 1662554..1663033 - 480 WP_021339947.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13432.59 Da        Isoelectric Point: 10.2178

>T186595 WP_002511418.1 NZ_CP068069:c1658617-1658255 [Staphylococcus equorum]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSESKMKEVNVAIDISLGLHNVRNSKS

Download         Length: 363 bp

>T186595 NZ_CP089610:c1946263-1945874 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6305.92 Da        Isoelectric Point: 4.0121

>AT186595 WP_002507108.1 NZ_CP068069:c1658784-1658614 [Staphylococcus equorum]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYLSSKNNNE

Download         Length: 171 bp

>AT186595 NZ_CP089610:c1946487-1946260 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7S376

Antitoxin

Source ID Structure
AlphaFold DB J9GY23

References