186586

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 398778..399307 Replicon chromosome
Accession NZ_CP068063
Organism Staphylococcus equorum strain FDAARGOS_1150

Toxin (Protein)


Gene name mazF Uniprot ID K7S376
Locus tag I6J07_RS02040 Protein ID WP_002511418.1
Coordinates 398945..399307 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID J9GY23
Locus tag I6J07_RS02035 Protein ID WP_002507108.1
Coordinates 398778..398948 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J07_RS02010 394529..395008 + 480 WP_002507103.1 PH domain-containing protein -
I6J07_RS02015 395001..396506 + 1506 WP_002507104.1 PH domain-containing protein -
I6J07_RS02020 396499..397035 + 537 WP_002507105.1 PH domain-containing protein -
I6J07_RS02025 397068..397418 + 351 WP_002507106.1 holo-ACP synthase -
I6J07_RS02030 397542..398690 + 1149 WP_002507107.1 alanine racemase -
I6J07_RS02035 398778..398948 + 171 WP_002507108.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I6J07_RS02040 398945..399307 + 363 WP_002511418.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6J07_RS02045 399672..400673 + 1002 WP_002507111.1 PP2C family protein-serine/threonine phosphatase -
I6J07_RS02050 400753..401079 + 327 WP_002511417.1 anti-sigma factor antagonist -
I6J07_RS02055 401081..401563 + 483 WP_002507113.1 anti-sigma B factor RsbW -
I6J07_RS02060 401538..402308 + 771 WP_002507114.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13432.59 Da        Isoelectric Point: 10.2178

>T186586 WP_002511418.1 NZ_CP068063:398945-399307 [Staphylococcus equorum]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSESKMKEVNVAIDISLGLHNVRNSKS

Download         Length: 363 bp

>T186586 NZ_CP089610:1172673-1173554 [Mycobacterium tuberculosis]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCCATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6305.92 Da        Isoelectric Point: 4.0121

>AT186586 WP_002507108.1 NZ_CP068063:398778-398948 [Staphylococcus equorum]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYLSSKNNNE

Download         Length: 171 bp

>AT186586 NZ_CP089610:1172053-1172676 [Mycobacterium tuberculosis]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTACGCGCTCGGCCGAAGCGAGCATCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7S376

Antitoxin

Source ID Structure
AlphaFold DB J9GY23

References