Detailed information of TA system TA186585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 387304..387824
• Replicon: chromosome
• Accession: NZ_CP068063
• Organism: Staphylococcus equorum strain FDAARGOS_1150

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: I6J07_RS01980
• Protein ID: WP_040762585.1
• Coordinates: 387612..387824 (+)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: J9GWP4
• Locus tag: I6J07_RS01975
• Protein ID: WP_002507096.1
• Coordinates: 387304..387597 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J07_RS01950	382441..383232	+	792	WP_103170215.1	hydroxyethylthiazole kinase	-
I6J07_RS01955	383232..383870	+	639	WP_002507092.1	thiamine phosphate synthase	-
I6J07_RS01960	383958..384827	+	870	WP_002507093.1	membrane protein insertase YidC	-
I6J07_RS01965	384898..385548	-	651	WP_002507094.1	HD domain-containing protein	-
I6J07_RS01970	385676..387160	-	1485	WP_103170214.1	cardiolipin synthase	-
I6J07_RS01975	387304..387597	+	294	WP_002507096.1	copper-sensing transcriptional repressor CsoR	Antitoxin
I6J07_RS01980	387612..387824	+	213	WP_040762585.1	heavy-metal-associated domain-containing protein	Toxin
I6J07_RS01985	388037..388177	+	141	WP_002507098.1	hypothetical protein	-
I6J07_RS01990	388335..389537	-	1203	WP_002507099.1	rod shape-determining protein RodA	-
I6J07_RS01995	389812..390882	+	1071	WP_002507100.1	D-alanine--D-alanine ligase	-
I6J07_RS02000	390895..392250	+	1356	WP_002507101.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (18-67)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 8130.16 Da
• Isoelectric Point: 4.5086

>T186585 WP_040762585.1 NZ_CP068063:387612-387824 [Staphylococcus equorum]
VITKVIYISGIENETQQKHIEQQLKQLHGVHQVNIEIESNNGKIFIDFETPASLNNLEKEVYDLGYEILY

Nucleotide

• Length: 213 bp

>T186585 NZ_CP089610:1019919-1020353 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11195.87 Da
• Isoelectric Point: 6.4791

>AT186585 WP_002507096.1 NZ_CP068063:387304-387597 [Staphylococcus equorum]
MAEIQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNGVATKLLDHHMKSCIMEKVEQGQQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT186585 NZ_CP089610:1019734-1019913 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Structures

Antitoxin

• AlphaFold DB: J9GWP4