Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2141895..2142481 Replicon chromosome
Accession NZ_CP068061
Organism Mammaliicoccus vitulinus strain FDAARGOS_1153

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag I6J10_RS10645 Protein ID WP_103322579.1
Coordinates 2141895..2142227 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag I6J10_RS10650 Protein ID WP_103322578.1
Coordinates 2142221..2142481 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J10_RS10625 2137071..2138426 - 1356 WP_107536570.1 gluconate:H+ symporter -
I6J10_RS10630 2138789..2139571 + 783 WP_126578691.1 DeoR/GlpR family DNA-binding transcription regulator -
I6J10_RS10635 2139573..2140943 + 1371 WP_107559074.1 aminopeptidase P family N-terminal domain-containing protein -
I6J10_RS10640 2141037..2141645 - 609 WP_107592920.1 hypothetical protein -
I6J10_RS10645 2141895..2142227 - 333 WP_103322579.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6J10_RS10650 2142221..2142481 - 261 WP_103322578.1 AbrB family transcriptional regulator Antitoxin
I6J10_RS10655 2142698..2143879 - 1182 WP_119595658.1 NADP-dependent malic enzyme -
I6J10_RS10660 2143911..2145260 - 1350 WP_016912002.1 2-hydroxycarboxylate transporter family protein -
I6J10_RS10665 2145888..2146601 - 714 WP_103322573.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12516.52 Da        Isoelectric Point: 8.4783

>T186584 WP_103322579.1 NZ_CP068061:c2142227-2141895 [Mammaliicoccus vitulinus]
MVKQYDIIKLNLNPVQGNEKGNYRPCLVVNITEFTKQSGFAWVIPITSRKQSRYPTDVIVETEKGLINGVVDCAHIRTVD
LYTRSHQKVDVLKANKIEEVKDILTGIMDL

Download         Length: 333 bp

>T186584 NZ_CP089610:844914-845342 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9950.21 Da        Isoelectric Point: 5.2300

>AT186584 WP_103322578.1 NZ_CP068061:c2142481-2142221 [Mammaliicoccus vitulinus]
MSEPTNKAYAKVYKSGNGQVISIKKDMLEKAGFKIGDELVMNVKGNQIVLEKPNTFKDRWRKFIEDGGEYERGEYDWGES
VGREEW

Download         Length: 261 bp

>AT186584 NZ_CP089610:844633-844890 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References