Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1551849..1552388 Replicon chromosome
Accession NZ_CP068061
Organism Mammaliicoccus vitulinus strain FDAARGOS_1153

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PTI0
Locus tag I6J10_RS07730 Protein ID WP_016910942.1
Coordinates 1551849..1552220 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PTG6
Locus tag I6J10_RS07735 Protein ID WP_016910943.1
Coordinates 1552221..1552388 (-) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J10_RS07710 1549119..1549889 - 771 WP_016910938.1 RNA polymerase sigma factor SigB -
I6J10_RS07715 1549864..1550340 - 477 WP_016910939.1 anti-sigma B factor RsbW -
I6J10_RS07720 1550345..1550668 - 324 WP_016910940.1 anti-sigma factor antagonist -
I6J10_RS07725 1550742..1551746 - 1005 WP_016910941.1 PP2C family protein-serine/threonine phosphatase -
I6J10_RS07730 1551849..1552220 - 372 WP_016910942.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6J10_RS07735 1552221..1552388 - 168 WP_016910943.1 hypothetical protein Antitoxin
I6J10_RS07740 1552473..1553621 - 1149 WP_016910944.1 alanine racemase -
I6J10_RS07745 1553669..1554037 - 369 WP_107536898.1 holo-ACP synthase -
I6J10_RS07750 1554049..1554531 - 483 WP_107536899.1 PH domain-containing protein -
I6J10_RS07755 1554521..1556032 - 1512 WP_107536900.1 PH domain-containing protein -
I6J10_RS07760 1556022..1556501 - 480 WP_016910948.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13611.75 Da        Isoelectric Point: 9.9193

>T186583 WP_016910942.1 NZ_CP068061:c1552220-1551849 [Mammaliicoccus vitulinus]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDTAIAISLNLTLQQKFDALGNT

Download         Length: 372 bp

>T186583 NZ_CP089610:c759459-759022 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6120.58 Da        Isoelectric Point: 4.0121

>AT186583 WP_016910943.1 NZ_CP068061:c1552388-1552221 [Mammaliicoccus vitulinus]
MTSLTQNRTQSIEQTLKEGYRSMADLNLSLASEAYYSECEACDSNESHLASQQGE

Download         Length: 168 bp

>AT186583 NZ_CP089610:c759710-759456 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PTI0

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PTG6

References