Detailed information of TA system TA186582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1379172..1379922
• Replicon: chromosome
• Accession: NZ_CP068061
• Organism: Mammaliicoccus vitulinus strain FDAARGOS_1153

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: I6J10_RS06740
• Protein ID: WP_158278552.1
• Coordinates: 1379172..1379309 (-)
• Length: 46 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: I6J10_RS06745
• Protein ID: WP_016913145.1
• Coordinates: 1379323..1379922 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J10_RS06730	1375981..1377507	-	1527	WP_119595923.1	exopolyphosphatase	-
I6J10_RS06735	1377596..1378984	-	1389	WP_016912016.1	class II fumarate hydratase	-
I6J10_RS06740	1379172..1379309	-	138	WP_158278552.1	hypothetical protein	Toxin
I6J10_RS06745	1379323..1379922	-	600	WP_016913145.1	hypothetical protein	Antitoxin
I6J10_RS06750	1379970..1381121	-	1152	WP_119595924.1	N-acetylglucosamine-6-phosphate deacetylase	-
I6J10_RS06755	1381208..1381345	+	138	WP_016913147.1	hypothetical protein	-
I6J10_RS06760	1381375..1381848	-	474	WP_103323120.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
I6J10_RS06765	1381852..1382979	-	1128	WP_016913149.1	tRNA epoxyqueuosine(34) reductase QueG	-
I6J10_RS06770	1383133..1383894	-	762	WP_016912868.1	acetylglutamate kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (134-195)

Sequences

Toxin

Protein

• Length: 46 a.a.
• Molecular weight: 5375.67 Da
• Isoelectric Point: 3.6792

>T186582 WP_158278552.1 NZ_CP068061:c1379309-1379172 [Mammaliicoccus vitulinus]
MNKNPEEENEMVQDLDDVKELGKEMEQISEQNDEAYEEKKEEQDS

Nucleotide

• Length: 138 bp

>T186582 NZ_CP089610:c759459-759022 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22350.23 Da
• Isoelectric Point: 4.9814

>AT186582 WP_016913145.1 NZ_CP068061:c1379922-1379323 [Mammaliicoccus vitulinus]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGIHLDAENTSFFDELLDDVKKNPVNFSQIHVLDFDGKEDYYTELGV
PKKQVLKTDVGSDVESFIKDKVNTDKKKNKLMLDVITLTEDSRTGLDYNQAIHPAREVIVLVTGKEKAKAVSQLYEEPAN
GSVESAKLKQHRMVTVLLDNEAAQGLPEDVRSYFSIQFS

Nucleotide

• Length: 600 bp

>AT186582 NZ_CP089610:c758912-758667 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA