Detailed information of TA system TA186581

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2176156..2176707
• Replicon: chromosome
• Accession: NZ_CP068060
• Organism: Streptococcus anginosus strain FDAARGOS_1155

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I0SIJ7
• Locus tag: I6J12_RS10605
• Protein ID: WP_003034637.1
• Coordinates: 2176156..2176434 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I0SII5
• Locus tag: I6J12_RS10610
• Protein ID: WP_003034600.1
• Coordinates: 2176435..2176707 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J12_RS10570	2172263..2172517	-	255	WP_003034719.1	Txe/YoeB family addiction module toxin	-
I6J12_RS10575	2172510..2172776	-	267	WP_003034688.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
I6J12_RS10580	2173040..2174698	-	1659	WP_003034653.1	cell division protein FtsK	-
I6J12_RS10585	2174705..2175115	-	411	WP_003034661.1	DUF961 family protein	-
I6J12_RS10590	2175138..2175452	-	315	WP_000406626.1	hypothetical protein	-
I6J12_RS10595	2175567..2175794	-	228	WP_003034721.1	hypothetical protein	-
I6J12_RS10600	2175791..2176027	-	237	WP_003034655.1	hypothetical protein	-
I6J12_RS10605	2176156..2176434	-	279	WP_003034637.1	type II toxin-antitoxin system YafQ family toxin	Toxin
I6J12_RS10610	2176435..2176707	-	273	WP_003034600.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I6J12_RS10615	2177380..2177742	+	363	WP_003034723.1	helix-turn-helix domain-containing protein	-
I6J12_RS10620	2177749..2178600	+	852	WP_003034663.1	ImmA/IrrE family metallo-endopeptidase	-
I6J12_RS10625	2178620..2178973	-	354	WP_003034700.1	hypothetical protein	-
I6J12_RS10630	2179220..2179747	+	528	WP_003034714.1	hypothetical protein	-
I6J12_RS10635	2179774..2180292	+	519	WP_003034614.1	hypothetical protein	-
I6J12_RS10640	2180285..2181307	+	1023	WP_003034698.1	radical SAM protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2160908..2183206	22298

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10876.72 Da
• Isoelectric Point: 8.0384

>T186581 WP_003034637.1 NZ_CP068060:c2176434-2176156 [Streptococcus anginosus]
MYQVKFTSAFKKSYKRIKKRGLEIALLDEVIEKLRLGQTLEEKYRDHELKGNFVGFRECHIKPDWLLIYLIEDDILTLTL
ADTGSHADLFKM

Nucleotide

• Length: 279 bp

>T186581 NZ_CP089610:c758680-758372 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9932.42 Da
• Isoelectric Point: 5.0337

>AT186581 WP_003034600.1 NZ_CP068060:c2176707-2176435 [Streptococcus anginosus]
MATVPTQIRINETVKAQATSLFNDLGMDMSSAVNIFLRQCLLRGGLPFTVEVPNYSQKTLEALAEAKRISRDETVASYDN
LADLKKALEV

Nucleotide

• Length: 273 bp

>AT186581 NZ_CP089610:c758912-758667 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Structures

Toxin

• AlphaFold DB: I0SIJ7

Antitoxin

• AlphaFold DB: I0SII5