Detailed information of TA system TA186577

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 663632..665051
• Replicon: chromosome
• Accession: NZ_CP068060
• Organism: Streptococcus anginosus strain FDAARGOS_1155

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: I0S920
• Locus tag: I6J12_RS03230
• Protein ID: WP_003038104.1
• Coordinates: 664218..665051 (+)
• Length: 278 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: I0S927
• Locus tag: I6J12_RS03225
• Protein ID: WP_003038122.1
• Coordinates: 663632..664225 (+)
• Length: 198 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J12_RS03210	659593..661581	+	1989	WP_003038121.1	C40 family peptidase	-
I6J12_RS03215	661593..661883	+	291	WP_003038098.1	hypothetical protein	-
I6J12_RS03220	661858..663540	+	1683	WP_052832844.1	DUF4366 domain-containing protein	-
I6J12_RS03225	663632..664225	+	594	WP_003038122.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
I6J12_RS03230	664218..665051	+	834	WP_003038104.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6J12_RS03235	665065..665370	+	306	WP_003038130.1	HTH domain-containing protein	-
I6J12_RS03240	665479..667191	+	1713	WP_003038090.1	DNA topoisomerase 3	-
I6J12_RS03245	667287..668054	+	768	WP_003038088.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-266)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-50)

Sequences

Toxin

Protein

• Length: 278 a.a.
• Molecular weight: 32568.28 Da
• Isoelectric Point: 5.8189

>T186577 WP_003038104.1 NZ_CP068060:664218-665051 [Streptococcus anginosus]
MNKDKLRAICQKLSKETGLSFNAVQTHYFLESILEKIASSDESENFIFKGGFLLANVIGIRQRNTVDIDFLIRRFSLTEE
NIKQRFEKILQSGNDNGITYEIQKIEEIRKEDEYGGFRITVLCRLENIRQIIPLDIATGDPITPSEISYEYKSIFSDKFF
EICAYNIETMLAEKIQTVYKRGAFNSRSKDFYDIYILYHLKKEEIDFEHLKEACKNTFKHRSTDFNIDSILDVLVDLKME
KDLKTRWSSYQKRFSYAGEINFDAVIDIMIELVKNIR

Nucleotide

• Length: 834 bp

>T186577 NZ_CP089610:714163-714564 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin

Protein

• Length: 198 a.a.
• Molecular weight: 23465.97 Da
• Isoelectric Point: 7.7343

>AT186577 WP_003038122.1 NZ_CP068060:663632-664225 [Streptococcus anginosus]
MDYIKKIKEKLNKTGGVITSKELKNSNIPTIYLTRMVEKGELIRADRGIYIDSNGDYDEYYFFHNRCKVAVFSYVSALYL
QEFTDIIPNEMEVTVYKGYNPHRISGNVRIHYVTKEIYDLGMTECQTMFGNTVKVYDLERTICDFIKNRSEIETELFSKT
INKYVRYENKDLNKLYEYSKKMKIYEKVKEILEVVYE

Nucleotide

• Length: 594 bp

>AT186577 NZ_CP089610:713939-714166 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: I0S920

Antitoxin

• AlphaFold DB: I0S927