Detailed information of TA system TA186576

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1354278..1354902
• Replicon: chromosome
• Accession: NZ_CP068057
• Organism: Streptococcus dysgalactiae strain FDAARGOS_1157

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: I6J14_RS06825
• Protein ID: WP_115252573.1
• Coordinates: 1354555..1354902 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: I6J14_RS06820
• Protein ID: WP_003049231.1
• Coordinates: 1354278..1354565 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J14_RS06770	1349870..1350157	+	288	WP_115252578.1	hypothetical protein	-
I6J14_RS06775	1350147..1350341	+	195	WP_174221687.1	hypothetical protein	-
I6J14_RS06780	1350353..1350682	+	330	WP_115252577.1	hypothetical protein	-
I6J14_RS06785	1350685..1350954	+	270	WP_115252576.1	hypothetical protein	-
I6J14_RS06790	1350954..1351410	+	457	Protein_1338	phage replisome organizer N-terminal domain-containing protein	-
I6J14_RS06795	1351582..1351848	+	267	WP_115253238.1	DnaD domain protein	-
I6J14_RS06800	1351987..1352544	+	558	WP_115252575.1	hypothetical protein	-
I6J14_RS06805	1352618..1353106	+	489	Protein_1341	hypothetical protein	-
I6J14_RS06810	1353495..1353857	+	363	WP_115252574.1	DUF1492 domain-containing protein	-
I6J14_RS06815	1353832..1354209	+	378	WP_003049845.1	DUF1492 domain-containing protein	-
I6J14_RS06820	1354278..1354565	+	288	WP_003049231.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I6J14_RS06825	1354555..1354902	+	348	WP_115252573.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6J14_RS06830	1355193..1355951	-	759	Protein_1346	protein kinase family protein	-
I6J14_RS06835	1356015..1356824	-	810	WP_115252572.1	Eco47II family restriction endonuclease	-
I6J14_RS06840	1356825..1357826	-	1002	WP_115252571.1	DNA cytosine methyltransferase	-
I6J14_RS06845	1357895..1358713	-	819	WP_115253237.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1345098..1367856	22758

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-64)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13375.13 Da
• Isoelectric Point: 5.1643

>T186576 WP_115252573.1 NZ_CP068057:1354555-1354902 [Streptococcus dysgalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYVETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKVVFVSDIIHSKQDYIRLFKKK

Nucleotide

• Length: 348 bp

>T186576 NZ_CP089610:706643-707044 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10706.10 Da
• Isoelectric Point: 4.8550

>AT186576 WP_003049231.1 NZ_CP068057:1354278-1354565 [Streptococcus dysgalactiae]
MHVLEKNTQVNFKTNSELLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDRERTELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT186576 NZ_CP089610:706401-706646 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA