Detailed information of TA system TA186575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1155270..1155944
• Replicon: chromosome
• Accession: NZ_CP068057
• Organism: Streptococcus dysgalactiae strain FDAARGOS_1157

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: V6Z2K9
• Locus tag: I6J14_RS05800
• Protein ID: WP_015647112.1
• Coordinates: 1155270..1155452 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: I6J14_RS05805
• Protein ID: WP_115252655.1
• Coordinates: 1155492..1155944 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J14_RS05770	1150586..1150858	+	273	WP_017768772.1	hypothetical protein	-
I6J14_RS05775	1150855..1151718	+	864	WP_115252659.1	primase alpha helix C-terminal domain-containing protein	-
I6J14_RS05780	1151715..1153232	+	1518	WP_174221689.1	DNA primase family protein	-
I6J14_RS05785	1153561..1154001	+	441	WP_115252658.1	hypothetical protein	-
I6J14_RS05790	1154071..1154571	+	501	WP_115252657.1	hypothetical protein	-
I6J14_RS05795	1154698..1155081	+	384	WP_115252656.1	sigma-70 family RNA polymerase sigma factor	-
I6J14_RS05800	1155270..1155452	+	183	WP_015647112.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6J14_RS05805	1155492..1155944	+	453	WP_115252655.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6J14_RS05810	1156749..1157255	+	507	Protein_1155	transposase	-
I6J14_RS05815	1157435..1157707	-	273	WP_115252654.1	hypothetical protein	-
I6J14_RS05820	1157939..1159089	+	1151	WP_115276329.1	IS3 family transposase	-
I6J14_RS05825	1159113..1159532	+	420	WP_142758263.1	DDE-type integrase/transposase/recombinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-77)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6630.84 Da
• Isoelectric Point: 10.8207

>T186575 WP_015647112.1 NZ_CP068057:1155270-1155452 [Streptococcus dysgalactiae]
MPMTQKEMVKLLTANGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Nucleotide

• Length: 183 bp

>T186575 NZ_CP089610:c700724-700311 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16728.70 Da
• Isoelectric Point: 3.9076

>AT186575 WP_115252655.1 NZ_CP068057:1155492-1155944 [Streptococcus dysgalactiae]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINTLSLADNNPF
RDDEDIELIYDPSKSFISMVMVDVADYLGSQEPIKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Nucleotide

• Length: 453 bp

>AT186575 NZ_CP089610:c700957-700721 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Structures

Toxin

• AlphaFold DB: V6Z2K9