Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3633485..3634158 Replicon chromosome
Accession NZ_CP068050
Organism Burkholderia gladioli strain BBB-01

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JKG63_RS33690 Protein ID WP_181278638.1
Coordinates 3633973..3634158 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JKG63_RS33685 Protein ID WP_181278639.1
Coordinates 3633485..3633904 (-) Length 140 a.a.

Genomic Context

JKG63_RS33660JKG63_RS33665JKG63_RS33695JKG63_RS33700JKG63_RS33705JKG63_RS33670JKG63_RS33675JKG63_RS33680JKG63_RS33685JKG63_RS33690JKG63_RS33710JKG63_RS33715
Location: 3629000..3630379 (1380 bp)
Type: Others
Protein ID: WP_201446828.1
Location: 3630392..3631228 (837 bp)
Type: Others
Protein ID: WP_126241730.1
Location: 3634394..3635593 (1200 bp)
Type: Others
Protein ID: WP_098151359.1
Location: 3635692..3637014 (1323 bp)
Type: Others
Protein ID: WP_164466764.1
Location: 3637183..3637689 (507 bp)
Type: Others
Protein ID: WP_201446830.1
Location: 3631339..3631632 (294 bp)
Type: Others
Protein ID: WP_025100743.1
Location: 3631779..3632774 (996 bp)
Type: Others
Protein ID: WP_201446829.1
Location: 3632932..3633336 (405 bp)
Type: Others
Protein ID: WP_046574976.1
Location: 3633485..3633904 (420 bp)
Type: Antitoxin
Protein ID: WP_181278639.1
Location: 3633973..3634158 (186 bp)
Type: Toxin
Protein ID: WP_181278638.1
Location: 3637774..3638604 (831 bp)
Type: Others
Protein ID: WP_013691500.1
Location: 3638604..3638822 (219 bp)
Type: Others
Protein ID: WP_013691499.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JKG63_RS336603629000..3630379+1380WP_201446828.1MFS transporter-
JKG63_RS336653630392..3631228+837WP_126241730.1methyltransferase domain-containing protein-
JKG63_RS336703631339..3631632-294WP_025100743.1hypothetical protein-
JKG63_RS336753631779..3632774-996WP_201446829.1malate dehydrogenase-
JKG63_RS336803632932..3633336-405WP_046574976.1DUF305 domain-containing protein-
JKG63_RS336853633485..3633904-420WP_181278639.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
JKG63_RS336903633973..3634158-186WP_181278638.1type II toxin-antitoxin system HicA family toxinToxin
JKG63_RS336953634394..3635593+1200WP_098151359.1amidohydrolase-
JKG63_RS337003635692..3637014+1323WP_164466764.1MFS transporter-
JKG63_RS337053637183..3637689+507WP_201446830.1GNAT family N-acetyltransferase-
JKG63_RS337103637774..3638604-831WP_013691500.1type I methionyl aminopeptidase-
JKG63_RS337153638604..3638822-219WP_013691499.1ParD-like family protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-63)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6980.13 Da        Isoelectric Point: 10.8421

>T186570 WP_181278638.1 NZ_CP068050:c3634158-3633973 [Burkholderia gladioli]
MKYSEFRKWLKKQGAMFEKHRSGSSHYRVTLNGKTTIFPDHGSKEIGTGLVEAIKKQLGIK

Download         Length: 186 bp

>T186570 NZ_CP089610:367103-367528 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15261.78 Da        Isoelectric Point: 5.2252

>AT186570 WP_181278639.1 NZ_CP068050:c3633904-3633485 [Burkholderia gladioli]
MLSYPVTLTPDSNNSLLVTFQDVPEAISVGETIDEALAQALDALEAALEIYFDEKRAIPMPSKALPDQHVVTLPVLVASK
VFLANEMIGQKVRKAELARRLNVNQVQVDRLLKFGHGSKIEMVEAALRALGKQLEVRAI

Download         Length: 420 bp

>AT186570 NZ_CP089610:366885-367106 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References