Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3633485..3634158 Replicon chromosome
Accession NZ_CP068050
Organism Burkholderia gladioli strain BBB-01

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JKG63_RS33690 Protein ID WP_181278638.1
Coordinates 3633973..3634158 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JKG63_RS33685 Protein ID WP_181278639.1
Coordinates 3633485..3633904 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKG63_RS33660 3629000..3630379 + 1380 WP_201446828.1 MFS transporter -
JKG63_RS33665 3630392..3631228 + 837 WP_126241730.1 methyltransferase domain-containing protein -
JKG63_RS33670 3631339..3631632 - 294 WP_025100743.1 hypothetical protein -
JKG63_RS33675 3631779..3632774 - 996 WP_201446829.1 malate dehydrogenase -
JKG63_RS33680 3632932..3633336 - 405 WP_046574976.1 DUF305 domain-containing protein -
JKG63_RS33685 3633485..3633904 - 420 WP_181278639.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JKG63_RS33690 3633973..3634158 - 186 WP_181278638.1 type II toxin-antitoxin system HicA family toxin Toxin
JKG63_RS33695 3634394..3635593 + 1200 WP_098151359.1 amidohydrolase -
JKG63_RS33700 3635692..3637014 + 1323 WP_164466764.1 MFS transporter -
JKG63_RS33705 3637183..3637689 + 507 WP_201446830.1 GNAT family N-acetyltransferase -
JKG63_RS33710 3637774..3638604 - 831 WP_013691500.1 type I methionyl aminopeptidase -
JKG63_RS33715 3638604..3638822 - 219 WP_013691499.1 ParD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-63)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6980.13 Da        Isoelectric Point: 10.8421

>T186570 WP_181278638.1 NZ_CP068050:c3634158-3633973 [Burkholderia gladioli]
MKYSEFRKWLKKQGAMFEKHRSGSSHYRVTLNGKTTIFPDHGSKEIGTGLVEAIKKQLGIK

Download         Length: 186 bp

>T186570 NZ_CP089610:367103-367528 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15261.78 Da        Isoelectric Point: 5.2252

>AT186570 WP_181278639.1 NZ_CP068050:c3633904-3633485 [Burkholderia gladioli]
MLSYPVTLTPDSNNSLLVTFQDVPEAISVGETIDEALAQALDALEAALEIYFDEKRAIPMPSKALPDQHVVTLPVLVASK
VFLANEMIGQKVRKAELARRLNVNQVQVDRLLKFGHGSKIEMVEAALRALGKQLEVRAI

Download         Length: 420 bp

>AT186570 NZ_CP089610:366885-367106 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References