Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3050102..3050622 Replicon chromosome
Accession NZ_CP068050
Organism Burkholderia gladioli strain BBB-01

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag JKG63_RS31125 Protein ID WP_103694063.1
Coordinates 3050102..3050326 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JKG63_RS31130 Protein ID WP_036032828.1
Coordinates 3050323..3050622 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKG63_RS31110 3045795..3046286 - 492 WP_025097476.1 MarR family transcriptional regulator -
JKG63_RS31115 3046733..3048157 + 1425 WP_103694067.1 methyltransferase regulatory domain-containing protein -
JKG63_RS31120 3048261..3049814 - 1554 WP_201446761.1 hypothetical protein -
JKG63_RS31125 3050102..3050326 + 225 WP_103694063.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JKG63_RS31130 3050323..3050622 + 300 WP_036032828.1 putative addiction module antidote protein Antitoxin
JKG63_RS31135 3050727..3051917 - 1191 WP_201446762.1 MFS transporter -
JKG63_RS31140 3052564..3053970 + 1407 WP_201446763.1 type III secretion protein -
JKG63_RS31145 3054000..3054245 + 246 WP_013689020.1 hypothetical protein -
JKG63_RS31150 3054417..3054701 + 285 WP_172535078.1 hypothetical protein -
JKG63_RS31155 3054822..3055277 + 456 WP_013689018.1 CesT family type III secretion system chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(17-68)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-92)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8135.36 Da        Isoelectric Point: 9.9207

>T186569 WP_103694063.1 NZ_CP068050:3050102-3050326 [Burkholderia gladioli]
MAFFGYRIPDNRHACARGDGVSELRIDHGPGYRVYYMKRGRVVVILLCGGNKDSQGHDIAVAKAIAAQWKGSTI

Download         Length: 225 bp

>T186569 NZ_CP089610:366535-366837 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10596.95 Da        Isoelectric Point: 4.7420

>AT186569 WP_036032828.1 NZ_CP068050:3050323-3050622 [Burkholderia gladioli]
MKAVKFSRYDTVDYLQTEEEIAAYLDAAVEDGDPALIAAALGDIARARNISQLARDTGMSREGIYRALSGDGNPSFATVM
KIANALGLRISFRPATSSP

Download         Length: 300 bp

>AT186569 NZ_CP089610:366885-367106 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References