Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 46915..47437 Replicon plasmid pU90-5
Accession NZ_CP068040
Organism Escherichia coli strain U90

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag JKF55_RS26250 Protein ID WP_000220560.1
Coordinates 47156..47437 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag JKF55_RS26245 Protein ID WP_000121743.1
Coordinates 46915..47166 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKF55_RS26220 42586..42867 + 282 WP_001185482.1 hypothetical protein -
JKF55_RS26225 42892..43869 + 978 WP_001269910.1 hypothetical protein -
JKF55_RS26230 43866..44291 - 426 WP_000202942.1 hypothetical protein -
JKF55_RS26235 44359..44805 - 447 WP_000057426.1 hypothetical protein -
JKF55_RS26240 44845..45681 - 837 WP_001050931.1 replication initiation protein -
JKF55_RS26245 46915..47166 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
JKF55_RS26250 47156..47437 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JKF55_RS26255 47583..47906 + 324 WP_001181907.1 hypothetical protein -
JKF55_RS26260 47951..48196 + 246 WP_000356545.1 hypothetical protein -
JKF55_RS26265 48186..48401 + 216 WP_001180116.1 hypothetical protein -
JKF55_RS26270 48791..49978 - 1188 WP_000937591.1 IS91 family transposase -
JKF55_RS26275 49978..50343 - 366 WP_000091308.1 hypothetical protein -
JKF55_RS26280 50620..51807 - 1188 WP_116794643.1 IS91-like element IS91 family transposase -
JKF55_RS26285 51807..52172 - 366 WP_000124098.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - estIa / hlyC / hlyA / hlyB / hlyD 1..126454 126454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T186520 WP_000220560.1 NZ_CP068040:47156-47437 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T186520 NZ_CP089551:c1850929-1850747 [Pseudomonas sp. 7-41]
GTGGATAGCCGATATTTAATAGGCCATATCGTCGCCGACGGCTGGTATCTGGTGCGCGTCAGAGGTAGCCATCACCCCTT
CAAGCACCCGACGAAACCGGGGCTGGTGACAATTCCTCATCCGAAGAAGGACTTGTTGGACAAGACCGCCAAAAGCATGT
TGAAACAGGCACTGCTGAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT186520 WP_000121743.1 NZ_CP068040:46915-47166 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT186520 NZ_CP089551:c1850724-1850314 [Pseudomonas sp. 7-41]
ATGCTGTACCCCATCGCAATTTCTACTGGTGACGAAGACCATGCCTGGGGCGTGGAAGTCCCGGACATTCCTGGTTGCTA
CTCCGCCGGTGACGACTTGGACGACGCCATGGCCATGGCCCGTGAAGCGATTGAAGGCCACTTCGAAATTCTCGCCGAAG
ACGGTGCGCCGATTCCCAGCGCGCAGAAAGTCACCCTGCATGCAGCCAACCCCAAGTACGCCGGTTGCATGTGGGCAGTG
GTGGACATCGATGTCACCAAATACCTGGGCAAGGCGCAGAAACTCAACATCACCCTGCCAGGCTATTTGCTCAATCGTAT
CGATGAATACGTACTGCACCATCCCGAGGAAAAAAGCCGTTCGGGGTTCCTCGCGTCCGCAGCGCTCAAGGTGCTGCAAC
AGGATCGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References