Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3163337..3164105 Replicon chromosome
Accession NZ_CP068035
Organism Escherichia coli strain U90

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JKF55_RS15300 Protein ID WP_000854814.1
Coordinates 3163731..3164105 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3W4SUB1
Locus tag JKF55_RS15295 Protein ID WP_044863316.1
Coordinates 3163337..3163642 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKF55_RS15265 3160178..3160633 + 456 WP_000581504.1 hypothetical protein -
JKF55_RS15270 3160712..3160945 + 234 WP_001119729.1 DUF905 family protein -
JKF55_RS15275 3161045..3161863 + 819 WP_001234629.1 DUF945 domain-containing protein -
JKF55_RS15280 3161945..3162424 + 480 WP_000860087.1 antirestriction protein -
JKF55_RS15285 3162440..3162916 + 477 WP_001186726.1 RadC family protein -
JKF55_RS15290 3162979..3163200 + 222 WP_000692323.1 DUF987 domain-containing protein -
JKF55_RS15295 3163337..3163642 + 306 WP_044863316.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JKF55_RS15300 3163731..3164105 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JKF55_RS15305 3164102..3164296 + 195 WP_000988600.1 hypothetical protein -
JKF55_RS15310 3164309..3164422 + 114 WP_001161660.1 DUF957 domain-containing protein -
JKF55_RS15315 3164711..3164839 - 129 Protein_2983 transposase domain-containing protein -
JKF55_RS15320 3164911..3165093 + 183 WP_001016348.1 hypothetical protein -
JKF55_RS15325 3165194..3165523 - 330 WP_000450409.1 DUF496 family protein -
JKF55_RS15330 3165695..3166753 - 1059 WP_001200891.1 FUSC family protein -
JKF55_RS15335 3166951..3167424 - 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
JKF55_RS15340 3167543..3168709 - 1167 WP_001464461.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(2-96)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T186507 WP_000854814.1 NZ_CP068035:3163731-3164105 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T186507 NZ_CP089519:3891013-3891363 [Pseudomonas extremorientalis]
ATGGATGCTCTATTTATCGAACTACCGCCCTTCGAGCGGCATCGCAAGGACTATCTGAGTGACGAGCTTTTCCAGGGTTT
TCAACAAGAGTTGATGAAGAACCCGGAAGCAGGAGATGTGATCGAGGGAACAGGCGGACTGCGCAAGGTTCGCTTCATCG
ACGAGCGACGCAACAAAGGCAAGCGCGGTGGCCTGCGGGTCATTTACTACTGGTGGTCGGGCGGCACGCAATTCTGGCTG
TTCACCCTGTACGGCAAGCACGAACAGGATGACCTGACACCACAGCACAAAAAAGCCCTAAAACACATGCTGGACAGGGA
AATCAAAGCGAGAACACATCATGAAACGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11250.00 Da        Isoelectric Point: 7.2621

>AT186507 WP_044863316.1 NZ_CP068035:3163337-3163642 [Escherichia coli]
MPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCKA
DTLSSCGYVYLAVYPTPEMKN

Download         Length: 306 bp

>AT186507 NZ_CP089519:3891353-3891667 [Pseudomonas extremorientalis]
ATGAAACGTGAAATTTTTTCCGAACTGGTCGAAGGCTTCGACGCCCTGGCAAACGAACGCCAGGGCAAAGTCACCCTGCG
AACCCATAAGGTTCATCTCAATCAACTGGAGCCGCTTACCGCCGAGGAGGTGGTGGCCGTGCGTCAACAACTCAACCTCT
CCCGGTCGGTGTTCGCCATGTACCTGCGCACCAACACCCGCACCCTGGAAAACTGGGAACAAGGTCGGGCCAAGCCAAAT
GCCCAGGCCGCCACCCTGATTCGCCTGGTGGCACGTTTCCCGGAAACCGTAGCGCAACTCGCTGCATTGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A3W4SUB1

References