Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 745329..746143 Replicon chromosome
Accession NZ_CP068035
Organism Escherichia coli strain U90

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JKF55_RS03580 Protein ID WP_001054376.1
Coordinates 745886..746143 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag JKF55_RS03575 Protein ID WP_001309181.1
Coordinates 745329..745874 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKF55_RS03545 741020..742333 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
JKF55_RS03550 742345..742623 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
JKF55_RS03555 742620..743741 - 1122 WP_000010829.1 M42 family metallopeptidase -
JKF55_RS03560 743986..744102 - 117 Protein_679 VOC family protein -
JKF55_RS03565 744140..744358 - 219 Protein_680 hypothetical protein -
JKF55_RS03570 744527..745273 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JKF55_RS03575 745329..745874 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
JKF55_RS03580 745886..746143 - 258 WP_001054376.1 hypothetical protein Toxin
JKF55_RS03585 746520..746765 - 246 Protein_684 GNAT family N-acetyltransferase -
JKF55_RS03590 746881..748121 + 1241 Protein_685 DNA helicase -
JKF55_RS03595 748704..749684 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
JKF55_RS03600 749749..750855 - 1107 WP_064986929.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T186490 WP_001054376.1 NZ_CP068035:c746143-745886 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T186490 NZ_CP089509:1835085-1835187 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT186490 WP_001309181.1 NZ_CP068035:c745874-745329 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT186490 NZ_CP089509:c1835194-1835049 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References