Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3933001..3933620 Replicon chromosome
Accession NZ_CP068033
Organism Klebsiella pneumoniae strain LYS105A

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JKA77_RS19170 Protein ID WP_002892050.1
Coordinates 3933402..3933620 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JKA77_RS19165 Protein ID WP_002892066.1
Coordinates 3933001..3933375 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKA77_RS19155 3928153..3929346 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JKA77_RS19160 3929369..3932515 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JKA77_RS19165 3933001..3933375 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JKA77_RS19170 3933402..3933620 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JKA77_RS19175 3933779..3934345 + 567 WP_002892030.1 maltose O-acetyltransferase -
JKA77_RS19180 3934317..3934457 - 141 WP_004147370.1 hypothetical protein -
JKA77_RS19185 3934478..3934948 + 471 WP_002892026.1 YlaC family protein -
JKA77_RS19190 3934923..3936374 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JKA77_RS19195 3936475..3937173 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
JKA77_RS19200 3937170..3937310 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JKA77_RS19205 3937310..3937573 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T186481 WP_002892050.1 NZ_CP068033:3933402-3933620 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T186481 NZ_CP089448:1965238-1965570 [Klebsiella michiganensis]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGTTACCCGTTGTTGTTCCCATCACCAGCGGTGGAAATTTTGCTCGCA
CGGCAGGTTTCACCGTTTCACTGGAAGGGGCAGGGACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGACTGCCCGGAACGGCAAGCGGCTGGAACGCATACCAGACGCTGTGGTAAATGAAGTGCTTGCCAGGCTGGATGC
AATTTTACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT186481 WP_002892066.1 NZ_CP068033:3933001-3933375 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT186481 NZ_CP089448:1964980-1965237 [Klebsiella michiganensis]
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACGCTGGAGCT
GTCGATGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCATTATTCTC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCTCCTGCGGTG
GGCAAGGAGATCCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References