Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 836209..836866 Replicon chromosome
Accession NZ_CP068033
Organism Klebsiella pneumoniae strain LYS105A

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JKA77_RS04195 Protein ID WP_002916310.1
Coordinates 836456..836866 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JKA77_RS04190 Protein ID WP_002916312.1
Coordinates 836209..836475 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKA77_RS04165 831365..832798 - 1434 WP_064145187.1 6-phospho-beta-glucosidase -
JKA77_RS04170 832917..833645 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JKA77_RS04175 833695..834006 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JKA77_RS04180 834170..834829 + 660 WP_002916317.1 hemolysin III family protein -
JKA77_RS04185 834980..835963 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JKA77_RS04190 836209..836475 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JKA77_RS04195 836456..836866 + 411 WP_002916310.1 protein YgfX Toxin
JKA77_RS04200 836873..837394 - 522 WP_004144730.1 flavodoxin FldB -
JKA77_RS04205 837495..838391 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JKA77_RS04210 838414..839127 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JKA77_RS04215 839133..840866 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T186472 WP_002916310.1 NZ_CP068033:836456-836866 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T186472 NZ_CP089445:5082570-5082881 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT186472 WP_002916312.1 NZ_CP068033:836209-836475 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT186472 NZ_CP089445:5082882-5083172 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References