Detailed information of TA system TA186468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 961086..961883
• Replicon: chromosome
• Accession: NZ_CP068031
• Organism: Staphylococcus saccharolyticus strain DVP5-16-4677

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: DMB75_RS04660
• Protein ID: WP_130547686.1
• Coordinates: 961710..961883 (+)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: DMB75_RS04655
• Protein ID: WP_130547687.1
• Coordinates: 961086..961685 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DMB75_RS04630	956122..957180	+	1059	WP_130547689.1	PTS transporter subunit IIC	-
DMB75_RS04635	957324..958763	+	1440	Protein_880	ABC transporter substrate-binding protein/permease	-
DMB75_RS04640	958756..959477	+	722	Protein_881	amino acid ABC transporter ATP-binding protein	-
DMB75_RS04645	959617..960447	+	831	Protein_882	DUF1730 domain-containing protein	-
DMB75_RS04650	960444..960914	+	471	WP_130547688.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
DMB75_RS04655	961086..961685	+	600	WP_130547687.1	glucosamine-6-phosphate isomerase	Antitoxin
DMB75_RS04660	961710..961883	+	174	WP_130547686.1	hypothetical protein	Toxin
DMB75_RS04665	962021..962425	+	405	WP_130547685.1	hypothetical protein	-
DMB75_RS04670	962797..964182	+	1386	WP_130547684.1	class II fumarate hydratase	-
DMB75_RS04675	964272..965096	-	825	WP_130547683.1	RluA family pseudouridine synthase	-
DMB75_RS04680	965255..966364	+	1110	WP_130547682.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6637.18 Da
• Isoelectric Point: 4.4777

>T186468 WP_130547686.1 NZ_CP068031:961710-961883 [Staphylococcus saccharolyticus]
MSNKKNSKLNYHEEENAMVSDLDDLKELGKEMEHISEKNDENKVNQSHDEICSDKTN

Nucleotide

• Length: 174 bp

>T186468 NZ_CP089445:4273692-4274156 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22830.72 Da
• Isoelectric Point: 4.6900

>AT186468 WP_130547687.1 NZ_CP068031:961086-961685 [Staphylococcus saccharolyticus]
MAMNFKVFDNNDRVAEYAADIIRKQFNNNPTTIAGFHLDQEHAPVLDELKKNVDCHAVDFSQINILDYDNNRSYYEILGV
PEGQVYSISYDQDAIEFISDKMKTKENKGKLILQVLSIDENGKLDVNVRQGLMEAREIFLIITGSQKRDVVEKLYRENGK
SSYEPADLKAHRMVNVILDKESAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT186468 NZ_CP089445:4273357-4273692 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA