Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 961086..961883 Replicon chromosome
Accession NZ_CP068031
Organism Staphylococcus saccharolyticus strain DVP5-16-4677

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag DMB75_RS04660 Protein ID WP_130547686.1
Coordinates 961710..961883 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag DMB75_RS04655 Protein ID WP_130547687.1
Coordinates 961086..961685 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMB75_RS04630 956122..957180 + 1059 WP_130547689.1 PTS transporter subunit IIC -
DMB75_RS04635 957324..958763 + 1440 Protein_880 ABC transporter substrate-binding protein/permease -
DMB75_RS04640 958756..959477 + 722 Protein_881 amino acid ABC transporter ATP-binding protein -
DMB75_RS04645 959617..960447 + 831 Protein_882 DUF1730 domain-containing protein -
DMB75_RS04650 960444..960914 + 471 WP_130547688.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DMB75_RS04655 961086..961685 + 600 WP_130547687.1 glucosamine-6-phosphate isomerase Antitoxin
DMB75_RS04660 961710..961883 + 174 WP_130547686.1 hypothetical protein Toxin
DMB75_RS04665 962021..962425 + 405 WP_130547685.1 hypothetical protein -
DMB75_RS04670 962797..964182 + 1386 WP_130547684.1 class II fumarate hydratase -
DMB75_RS04675 964272..965096 - 825 WP_130547683.1 RluA family pseudouridine synthase -
DMB75_RS04680 965255..966364 + 1110 WP_130547682.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6637.18 Da        Isoelectric Point: 4.4777

>T186468 WP_130547686.1 NZ_CP068031:961710-961883 [Staphylococcus saccharolyticus]
MSNKKNSKLNYHEEENAMVSDLDDLKELGKEMEHISEKNDENKVNQSHDEICSDKTN

Download         Length: 174 bp

>T186468 NZ_CP089445:4273692-4274156 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22830.72 Da        Isoelectric Point: 4.6900

>AT186468 WP_130547687.1 NZ_CP068031:961086-961685 [Staphylococcus saccharolyticus]
MAMNFKVFDNNDRVAEYAADIIRKQFNNNPTTIAGFHLDQEHAPVLDELKKNVDCHAVDFSQINILDYDNNRSYYEILGV
PEGQVYSISYDQDAIEFISDKMKTKENKGKLILQVLSIDENGKLDVNVRQGLMEAREIFLIITGSQKRDVVEKLYRENGK
SSYEPADLKAHRMVNVILDKESAEGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT186468 NZ_CP089445:4273357-4273692 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References