Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 824423..824952 Replicon chromosome
Accession NZ_CP068031
Organism Staphylococcus saccharolyticus strain DVP5-16-4677

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DMB75_RS03890 Protein ID WP_130548321.1
Coordinates 824590..824952 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DMB75_RS03885 Protein ID WP_115312958.1
Coordinates 824423..824593 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMB75_RS03860 820237..820715 + 479 Protein_757 PH domain-containing protein -
DMB75_RS03865 820708..822206 + 1499 Protein_758 PH domain-containing protein -
DMB75_RS03870 822193..822675 + 483 WP_130548324.1 PH domain-containing protein -
DMB75_RS03875 822758..823111 + 354 WP_130548323.1 holo-ACP synthase -
DMB75_RS03880 823188..824336 + 1149 WP_130548322.1 alanine racemase -
DMB75_RS03885 824423..824593 + 171 WP_115312958.1 antitoxin MazE Antitoxin
DMB75_RS03890 824590..824952 + 363 WP_130548321.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DMB75_RS03895 825303..826305 + 1003 Protein_764 PP2C family protein-serine/threonine phosphatase -
DMB75_RS03900 826407..826733 + 327 WP_130548319.1 anti-sigma factor antagonist -
DMB75_RS03905 826735..827214 + 480 WP_115312962.1 anti-sigma B factor RsbW -
DMB75_RS03910 827189..827959 + 771 WP_130548318.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13533.68 Da        Isoelectric Point: 10.0249

>T186467 WP_130548321.1 NZ_CP068031:824590-824952 [Staphylococcus saccharolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDQQKS

Download         Length: 363 bp

>T186467 NZ_CP089445:c4232376-4232062 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6257.82 Da        Isoelectric Point: 3.6326

>AT186467 WP_115312958.1 NZ_CP068031:824423-824593 [Staphylococcus saccharolyticus]
MLSFNQTRTNSLEQSLKEGYSQMADLNLSLATEAFPIECEACDCNETYLTSNSQSE

Download         Length: 171 bp

>AT186467 NZ_CP089445:c4232065-4231649 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References