Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 813192..813691 Replicon chromosome
Accession NZ_CP068031
Organism Staphylococcus saccharolyticus strain DVP5-16-4677

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag DMB75_RS03825 Protein ID WP_130548329.1
Coordinates 813512..813691 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag DMB75_RS03820 Protein ID WP_130548330.1
Coordinates 813192..813485 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMB75_RS03795 808318..809106 + 789 WP_130548334.1 hydroxyethylthiazole kinase -
DMB75_RS03800 809110..809751 + 642 WP_130548333.1 thiamine phosphate synthase -
DMB75_RS03805 809840..810712 + 873 WP_130548332.1 membrane protein insertase YidC -
DMB75_RS03810 810713..811418 - 706 Protein_747 HD domain-containing protein -
DMB75_RS03815 811523..813007 - 1485 WP_130548331.1 cardiolipin synthase -
DMB75_RS03820 813192..813485 + 294 WP_130548330.1 copper-sensing transcriptional repressor CsoR Antitoxin
DMB75_RS03825 813512..813691 + 180 WP_130548329.1 heavy-metal-associated domain-containing protein Toxin
DMB75_RS03830 813831..813968 + 138 WP_115312949.1 hypothetical protein -
DMB75_RS03835 814166..815377 - 1212 WP_130548328.1 rod shape-determining protein RodA -
DMB75_RS03840 815548..815712 + 165 WP_165418024.1 hypothetical protein -
DMB75_RS03845 815784..816854 + 1071 WP_130548327.1 D-alanine--D-alanine ligase -
DMB75_RS03850 816870..818225 + 1356 WP_130548326.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6453.33 Da        Isoelectric Point: 7.2000

>T186466 WP_130548329.1 NZ_CP068031:813512-813691 [Staphylococcus saccharolyticus]
IIHVSGIETGEQEAQLTKLLSKMIGAQSVTANRISGIRTPKNLNSIEKEIYDSGYHVVN

Download         Length: 180 bp

>T186466 NZ_CP089445:4056868-4057245 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11003.51 Da        Isoelectric Point: 5.5723

>AT186466 WP_130548330.1 NZ_CP068031:813192-813485 [Staphylococcus saccharolyticus]
MTENDTAHHSEQTKANLKSRLNRIEGQVCAINRMIEDDVYCDDVLTQIKATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT186466 NZ_CP089445:4056411-4056779 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References