Detailed information of TA system TA186465

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1866153..1866629
• Replicon: chromosome
• Accession: NZ_CP068029
• Organism: Staphylococcus saccharolyticus strain 13T0028

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: -
• Locus tag: DMB76_RS09065
• Protein ID: WP_115313761.1
• Coordinates: 1866441..1866629 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: DMB76_RS09060
• Protein ID: WP_115313760.1
• Coordinates: 1866153..1866410 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DMB76_RS09025	1861534..1862076	-	543	WP_115313754.1	nitroreductase	-
DMB76_RS09030	1862155..1862871	-	717	WP_115313755.1	type I 3-dehydroquinate dehydratase	-
DMB76_RS09035	1863036..1863458	+	423	WP_115313756.1	organic hydroperoxide resistance protein	-
DMB76_RS09040	1863863..1864369	+	507	WP_115313757.1	GNAT family N-acetyltransferase	-
DMB76_RS09045	1864475..1865047	-	573	WP_185802537.1	phosphoglycerate mutase family protein	-
DMB76_RS09050	1865284..1865520	+	237	WP_115313759.1	hypothetical protein	-
DMB76_RS09055	1865512..1865705	-	194	Protein_1751	hypothetical protein	-
DMB76_RS09060	1866153..1866410	+	258	WP_115313760.1	hypothetical protein	Antitoxin
DMB76_RS09065	1866441..1866629	+	189	WP_115313761.1	hypothetical protein	Toxin
DMB76_RS09070	1866834..1867412	+	579	WP_115313762.1	hypothetical protein	-
DMB76_RS09075	1867472..1867705	-	234	WP_115313763.1	hypothetical protein	-
DMB76_RS09080	1868104..1868841	+	738	WP_115313764.1	poly-gamma-glutamate hydrolase family protein	-
DMB76_RS09085	1868945..1869229	+	285	WP_115313765.1	hypothetical protein	-
DMB76_RS09090	1869771..1870346	+	576	WP_165417903.1	hypothetical protein	-
DMB76_RS09095	1870426..1870602	-	177	WP_115313768.1	cold-shock protein	-
DMB76_RS09100	1871346..1871417	+	72	WP_126517390.1	epsilon family phenol-soluble modulin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7194.98 Da
• Isoelectric Point: 9.6269

>T186465 WP_115313761.1 NZ_CP068029:1866441-1866629 [Staphylococcus saccharolyticus]
MSLHFYILLWLAILFIIAGTILLITMLKTKKEERKESYLGFTVIFLIFGIAILIYTLIFGIL

Nucleotide

• Length: 189 bp

>T186465 NZ_CP089445:c3911895-3911488 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9892.03 Da
• Isoelectric Point: 3.9522

>AT186465 WP_115313760.1 NZ_CP068029:1866153-1866410 [Staphylococcus saccharolyticus]
MKLIRINVINVILTILFMAFNVLITYNENIDNNLWLVPGLIICGITLLTSLTIAIVYTDLFSEILFFINIILALYYIYPI
LYEFI

Nucleotide

• Length: 258 bp

>AT186465 NZ_CP089445:c3912142-3911876 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA