Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 968552..969349 Replicon chromosome
Accession NZ_CP068029
Organism Staphylococcus saccharolyticus strain 13T0028

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag DMB76_RS04750 Protein ID WP_115313055.1
Coordinates 969176..969349 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag DMB76_RS04745 Protein ID WP_115313054.1
Coordinates 968552..969151 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMB76_RS04720 963686..964744 + 1059 WP_115313052.1 PTS transporter subunit IIC -
DMB76_RS04725 964889..965934 + 1046 Protein_896 ABC transporter substrate-binding protein/permease -
DMB76_RS04730 965927..966655 + 729 Protein_897 amino acid ABC transporter ATP-binding protein -
DMB76_RS04735 966781..967910 + 1130 Protein_898 tRNA epoxyqueuosine(34) reductase QueG -
DMB76_RS04740 967907..968377 + 471 WP_115313053.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DMB76_RS04745 968552..969151 + 600 WP_115313054.1 glucosamine-6-phosphate isomerase Antitoxin
DMB76_RS04750 969176..969349 + 174 WP_115313055.1 hypothetical protein Toxin
DMB76_RS04755 969487..969891 + 405 WP_115313056.1 hypothetical protein -
DMB76_RS04760 970262..971647 + 1386 WP_115313057.1 class II fumarate hydratase -
DMB76_RS04765 971742..972566 - 825 WP_115313058.1 RluA family pseudouridine synthase -
DMB76_RS04770 972725..973834 + 1110 Protein_905 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6652.19 Da        Isoelectric Point: 4.3747

>T186464 WP_115313055.1 NZ_CP068029:969176-969349 [Staphylococcus saccharolyticus]
MSNKKNSKLNYHEEENAMVTDLDDLKELGKEMEHISEKNDEDKVNQSHDEICSDKTN

Download         Length: 174 bp

>T186464 NZ_CP089445:c3582971-3581901 [Escherichia coli]
ATGACAGTCAGGAACTACACTAATTTAAATTTAGATCGGACAACTATTGAGGCTACGTCTAGGGCATTTATTGAAAATAA
AAACTATTCCGTCCATTCAATTGGACCAATGCCTGGTGCAAGAGCAGGACTTCGGGTTGTGTTTGCTAAACCAGGAGAAG
CTTTGGCAACTGTTAACATTTTTTATAATAACGGAGGGACGTCTACAGTCCAGTATCAAACAGGAGCTAATCGTAATCTT
GGAAAAGAGTTGGCTGATAATCTCTATGAAACCATCAATCCTGCAGAATTTGAACAGGTAAATATGGTGTTACAAGGGTT
CGTTGAAGCGAACGTTTTATCTGTACTTCAGCTCTCAGCAGAGCAGCCACATATACAATTTTACGAATACTTACGGAACA
CTCATACAACGGTGTGGAAAATTCATTCGCCAGAATTTCAGGATGAGTTGACAGTTAGTCTGCATCACAGAAATGGAACA
CTACAAATACAAGGGCGTCCATTGTCATGTTATAGAGTGTTTATATTCAACTTGTCAGAGCTACTCGATTTACAAGGACT
GGAAAAAGTTCTCATTCGTCAGGACGATGGCAAAGCGTATATAGTTCAGAAAGAAGTTGCTCGCTCACATCTAGAGTGTG
AAATGGGGGATGCGTACCCACTATTGCATAAGAATGTTGAAAAATTGCTCGTTTCTGGGCTGTGTGTTAAACTCGCCGCC
CCCGATTTACCCGATTACTGTATGTTGTTGTATCCTGAATTACGTTCAGTTGAGGGAGTACTTAAATCAACAATGTACCG
ATATGGCATGCCAATCACGCAGGATGGTTTCGGGCCTTATTTTGATAAAATTGGGAGTGAATTTATTCTGAAACAACAAT
TTGGACGCAATTTATCGTCAGCTAAGGTTAAGACCATTAATGATGCCTATACTTTCTTTAACAGAGAACGTCATGGCCTG
TTTCATATGGAGATAGTTGTCGACACAAGCCGTATGGTTTCTGACATGGCACGACTGATGACTAAGGCCAGACAGGCATG
GGGAATTATTAAGGATTTGTATATTGTTTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22746.65 Da        Isoelectric Point: 4.8725

>AT186464 WP_115313054.1 NZ_CP068029:968552-969151 [Staphylococcus saccharolyticus]
MAMNFKVFDNNDRVAEYAADIIRKQFNNNPTTIAGFHLDKEHAPVLDELKKNVDCHAVDFSQINILDYDNNRSYYETLGV
PEGQVYSISYDQDAIGFISDKMKTKENKGKLILQVLSIDENGKLDVNVRQGLMEAREIFLIITGSQKRDVVEKLYRENGK
SSYEPADLKAHRMVNVILDKESAEGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT186464 NZ_CP089445:c3581908-3581546 [Escherichia coli]
TTGTTTGAAATAACAGGTGTTAACGTCTCAGGGGCTCTCATTGCCGTCGTTATGGCGACTGGCTACGAGAACCCCTTGAC
TTCAGTTCACGAAATCGAGAAGAGGCTTTCTGTTATACTGGGCAATTCACAGGCTACAGGTGAGGTTTTGTTTGACCTTT
TGTGTTCTAATGGTCCAGAGTGGAATCGCTTTGTTTCGCTGGAAATAAGGTGTGGCAGTATTTTGCTGGATACTGCCAAA
ATTGTGGATGAGCAAGAAATTCCAGCGCAGATCTTGAGACATCAGAGAGATGTATTACGTAACCACCCTGAGTACGTAGA
AGACTCTGTGTTAACACCAGATGATGTTCTTTGTATTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References