Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 832994..833523 Replicon chromosome
Accession NZ_CP068029
Organism Staphylococcus saccharolyticus strain 13T0028

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DMB76_RS03935 Protein ID WP_115312959.1
Coordinates 833161..833523 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DMB76_RS03930 Protein ID WP_115312958.1
Coordinates 832994..833164 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMB76_RS03905 828781..829293 + 513 Protein_768 PH domain-containing protein -
DMB76_RS03910 829286..830787 + 1502 Protein_769 PH domain-containing protein -
DMB76_RS03915 830774..831226 + 453 WP_115312955.1 PH domain-containing protein -
DMB76_RS03920 831337..831699 + 363 WP_115312956.1 holo-ACP synthase -
DMB76_RS03925 831759..832907 + 1149 WP_115312957.1 alanine racemase -
DMB76_RS03930 832994..833164 + 171 WP_115312958.1 antitoxin MazE Antitoxin
DMB76_RS03935 833161..833523 + 363 WP_115312959.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DMB76_RS03940 833875..834876 + 1002 WP_115312960.1 PP2C family protein-serine/threonine phosphatase -
DMB76_RS03945 834978..835304 + 327 WP_115312961.1 anti-sigma factor antagonist -
DMB76_RS03950 835306..835785 + 480 WP_115312962.1 anti-sigma B factor RsbW -
DMB76_RS03955 835760..836530 + 771 WP_115312963.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13542.69 Da        Isoelectric Point: 10.0250

>T186463 WP_115312959.1 NZ_CP068029:833161-833523 [Staphylococcus saccharolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHQKS

Download         Length: 363 bp

>T186463 NZ_CP089445:c2943934-2943683 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6257.82 Da        Isoelectric Point: 3.6326

>AT186463 WP_115312958.1 NZ_CP068029:832994-833164 [Staphylococcus saccharolyticus]
MLSFNQTRTNSLEQSLKEGYSQMADLNLSLATEAFPIECEACDCNETYLTSNSQSE

Download         Length: 171 bp

>AT186463 NZ_CP089445:c2943686-2943432 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References