Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84084..85707 Replicon plasmid unnamed1
Accession NZ_CP068019
Organism Salmonella enterica strain 1722

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag JI996_RS25190 Protein ID WP_000088046.1
Coordinates 84382..85707 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag JI996_RS25185 Protein ID WP_024136327.1
Coordinates 84084..84377 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI996_RS25160 (JI996_25010) 79956..81197 + 1242 WP_001053338.1 VWA domain-containing protein -
JI996_RS25990 81288..81419 + 132 WP_000374059.1 hypothetical protein -
JI996_RS25165 (JI996_25015) 81760..82041 - 282 WP_000077926.1 hypothetical protein -
JI996_RS25170 (JI996_25020) 82091..82282 - 192 WP_000398480.1 hypothetical protein -
JI996_RS25175 (JI996_25025) 82374..82715 - 342 WP_001151575.1 hypothetical protein -
JI996_RS25180 (JI996_25030) 83088..83480 + 393 WP_000341066.1 hypothetical protein -
JI996_RS25185 (JI996_25035) 84084..84377 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
JI996_RS25190 (JI996_25040) 84382..85707 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
JI996_RS25195 (JI996_25045) 85768..85974 + 207 WP_000134171.1 hypothetical protein -
JI996_RS25200 (JI996_25050) 86076..86486 + 411 WP_000985911.1 hypothetical protein -
JI996_RS25205 (JI996_25055) 86499..87314 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
JI996_RS25210 (JI996_25060) 87568..87993 + 426 WP_001043843.1 hypothetical protein -
JI996_RS25215 (JI996_25065) 88542..88850 + 309 WP_001224687.1 hypothetical protein -
JI996_RS25220 (JI996_25070) 88866..89723 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
JI996_RS25225 (JI996_25075) 89785..89988 + 204 WP_001194555.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaNDM-5 / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr - 1..208610 208610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T186457 WP_000088046.1 NZ_CP068019:84382-85707 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T186457 NZ_CP089445:1283013-1283315 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT186457 WP_024136327.1 NZ_CP068019:84084-84377 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT186457 NZ_CP089445:1283351-1283692 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References