186454

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4585456..4586216 Replicon chromosome
Accession NZ_CP068018
Organism Salmonella enterica strain 1722

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag JI996_RS22670 Protein ID WP_000533909.1
Coordinates 4585456..4585941 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag JI996_RS22675 Protein ID WP_000965886.1
Coordinates 4585929..4586216 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI996_RS22640 (4580526) 4580526..4581188 + 663 WP_000747548.1 OmpA family lipoprotein -
JI996_RS22645 (4581407) 4581407..4582381 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
JI996_RS22650 (4582431) 4582431..4583141 - 711 WP_000190524.1 DUF3053 domain-containing protein -
JI996_RS22655 (4583580) 4583580..4583870 + 291 WP_000455790.1 HTH-type transcriptional regulator -
JI996_RS22660 (4584159) 4584159..4584371 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
JI996_RS22665 (4584545) 4584545..4585084 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
JI996_RS22670 (4585456) 4585456..4585941 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
JI996_RS22675 (4585929) 4585929..4586216 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
JI996_RS22680 (4586394) 4586394..4586861 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
JI996_RS22685 (4587033) 4587033..4587308 - 276 Protein_4435 IS3 family transposase -
JI996_RS22690 (4587490) 4587490..4589559 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
JI996_RS22695 (4589569) 4589569..4590480 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
JI996_RS22700 (4590619) 4590619..4590921 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T186454 WP_000533909.1 NZ_CP068018:c4585941-4585456 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T186454 NZ_CP089445:803263-803547 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT186454 WP_000965886.1 NZ_CP068018:c4586216-4585929 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT186454 NZ_CP089445:803027-803260 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References