Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3873015..3873675 Replicon chromosome
Accession NZ_CP068018
Organism Salmonella enterica strain 1722

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag JI996_RS19175 Protein ID WP_000244756.1
Coordinates 3873015..3873428 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag JI996_RS19180 Protein ID WP_000351186.1
Coordinates 3873409..3873675 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI996_RS19155 (3868956) 3868956..3870689 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
JI996_RS19160 (3870695) 3870695..3871408 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JI996_RS19165 (3871432) 3871432..3872328 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
JI996_RS19170 (3872441) 3872441..3872962 + 522 WP_001055885.1 flavodoxin FldB -
JI996_RS19175 (3873015) 3873015..3873428 - 414 WP_000244756.1 protein YgfX Toxin
JI996_RS19180 (3873409) 3873409..3873675 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
JI996_RS19185 (3873925) 3873925..3874905 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
JI996_RS19190 (3875021) 3875021..3875680 - 660 WP_000250289.1 hemolysin III family protein -
JI996_RS19195 (3875844) 3875844..3876155 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
JI996_RS19200 (3876314) 3876314..3877747 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T186451 WP_000244756.1 NZ_CP068018:c3873428-3873015 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T186451 NZ_CP089445:506519-506869 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT186451 WP_000351186.1 NZ_CP068018:c3873675-3873409 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT186451 NZ_CP089445:506274-506525 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References