186439

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1241558..1242178 Replicon chromosome
Accession NZ_CP068018
Organism Salmonella enterica strain 1722

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JI996_RS06025 Protein ID WP_001280991.1
Coordinates 1241558..1241776 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag JI996_RS06030 Protein ID WP_000344807.1
Coordinates 1241804..1242178 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI996_RS05985 (1236782) 1236782..1237351 + 570 WP_000779803.1 YbaY family lipoprotein -
JI996_RS05990 (1237384) 1237384..1237773 - 390 WP_000961285.1 MGMT family protein -
JI996_RS06000 (1238004) 1238004..1239554 - 1551 WP_000213139.1 EAL domain-containing protein -
JI996_RS06005 (1239779) 1239779..1240039 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
JI996_RS06010 (1240045) 1240045..1240185 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
JI996_RS06015 (1240241) 1240241..1240711 - 471 WP_000136181.1 YlaC family protein -
JI996_RS06020 (1240828) 1240828..1241379 - 552 WP_001278792.1 maltose O-acetyltransferase -
JI996_RS06025 (1241558) 1241558..1241776 - 219 WP_001280991.1 HHA domain-containing protein Toxin
JI996_RS06030 (1241804) 1241804..1242178 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
JI996_RS06035 (1242674) 1242674..1245823 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
JI996_RS06040 (1245846) 1245846..1247039 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T186439 WP_001280991.1 NZ_CP068018:c1241776-1241558 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T186439 NZ_CP089441:1827409-1827511 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT186439 WP_000344807.1 NZ_CP068018:c1242178-1241804 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT186439 NZ_CP089441:c1827517-1827368 [Klebsiella quasipneumoniae]
ACATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References