Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 359899..360680 Replicon chromosome
Accession NZ_CP068018
Organism Salmonella enterica strain 1722

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag JI996_RS01775 Protein ID WP_000626099.1
Coordinates 360189..360680 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag JI996_RS01770 Protein ID WP_001110452.1
Coordinates 359899..360192 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI996_RS01740 (356223) 356223..357128 + 906 WP_001268200.1 YjiK family protein -
JI996_RS01745 (357422) 357422..357691 - 270 WP_010989096.1 hypothetical protein -
JI996_RS01750 (357699) 357699..357914 - 216 WP_001595136.1 hypothetical protein -
JI996_RS01755 (357937) 357937..358224 - 288 WP_001269916.1 transcriptional regulator RtsB -
JI996_RS01760 (358221) 358221..359096 - 876 WP_000921674.1 AraC family transcriptional regulator -
JI996_RS01765 (359361) 359361..359582 - 222 WP_001576552.1 hypothetical protein -
JI996_RS01770 (359899) 359899..360192 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
JI996_RS01775 (360189) 360189..360680 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
JI996_RS01780 (360928) 360928..361680 - 753 WP_000842434.1 non-specific acid phosphatase -
JI996_RS01785 (361783) 361783..361857 - 75 Protein_343 porin family protein -
JI996_RS01790 (362890) 362890..363267 - 378 WP_000916345.1 EthD family reductase -
JI996_RS01795 (363339) 363339..363671 + 333 WP_001165471.1 MerR family transcriptional regulator -
JI996_RS01800 (363762) 363762..363839 + 78 Protein_346 helix-turn-helix domain-containing protein -
JI996_RS01810 (364110) 364110..364685 - 576 WP_001188509.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T186433 WP_000626099.1 NZ_CP068018:360189-360680 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T186433 NZ_CP089438:c14266-13916 [Citrobacter portucalensis]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT186433 WP_001110452.1 NZ_CP068018:359899-360192 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT186433 NZ_CP089438:c13911-13609 [Citrobacter portucalensis]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References