Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 161684..162354 | Replicon | plasmid pMS3802-CTXM-vir |
| Accession | NZ_CP068016 | ||
| Organism | Klebsiella pneumoniae strain 2016_49 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q6U619 |
| Locus tag | JKF56_RS27980 | Protein ID | WP_004213072.1 |
| Coordinates | 161684..162127 (-) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q6U620 |
| Locus tag | JKF56_RS27985 | Protein ID | WP_004213073.1 |
| Coordinates | 162124..162354 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JKF56_RS27945 (JKF56_27935) | 157118..157393 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
| JKF56_RS27950 (JKF56_27940) | 157456..157947 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
| JKF56_RS27955 (JKF56_27945) | 157996..158916 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
| JKF56_RS27960 (JKF56_27950) | 159007..159410 | + | 404 | Protein_173 | GAF domain-containing protein | - |
| JKF56_RS27965 (JKF56_27955) | 159926..160522 | - | 597 | Protein_174 | response regulator | - |
| JKF56_RS27970 (JKF56_27960) | 160957..161261 | + | 305 | Protein_175 | transposase | - |
| JKF56_RS29240 | 161284..161535 | - | 252 | WP_186987481.1 | hypothetical protein | - |
| JKF56_RS27980 (JKF56_27970) | 161684..162127 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| JKF56_RS27985 (JKF56_27975) | 162124..162354 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| JKF56_RS27990 (JKF56_27980) | 162962..164095 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
| JKF56_RS27995 (JKF56_27985) | 164111..164404 | + | 294 | WP_004213076.1 | hypothetical protein | - |
| JKF56_RS28000 (JKF56_27990) | 164394..164600 | - | 207 | WP_004213077.1 | hypothetical protein | - |
| JKF56_RS28005 (JKF56_27995) | 164952..165242 | + | 291 | WP_004213078.1 | hypothetical protein | - |
| JKF56_RS28010 (JKF56_28000) | 165232..166131 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaCTX-M-15 / blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 | iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA | 1..234774 | 234774 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T186432 WP_004213072.1 NZ_CP068016:c162127-161684 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T186432 NZ_CP089437:4952766-4953077 [Citrobacter portucalensis]
GTGCATGTTATCAGCCGAAAACCTTTTAACGAGGCAATGCTCATGTATCCAAATCATCAGCTTGCTCTCGCTGATTTACT
GAATGTTTTGGAGAAAAAAACATTCATTCAGCCTGAAGAGATGAAGCAGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACTGCCTAAGACTCATCTCCTACATAGATTTCAGGTCACATAAGATA
TTTGTCAAACATATCGTTTCCCATGCCGAATATGACAAACTGACAGCATATTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCTTTTAACGAGGCAATGCTCATGTATCCAAATCATCAGCTTGCTCTCGCTGATTTACT
GAATGTTTTGGAGAAAAAAACATTCATTCAGCCTGAAGAGATGAAGCAGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACTGCCTAAGACTCATCTCCTACATAGATTTCAGGTCACATAAGATA
TTTGTCAAACATATCGTTTCCCATGCCGAATATGACAAACTGACAGCATATTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT186432 WP_004213073.1 NZ_CP068016:c162354-162124 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT186432 NZ_CP089437:4953074-4953520 [Citrobacter portucalensis]
ATGAGAACGCATCGTCATATGGATGCAGCCAGCGCAAAAAAGATTGTTGATACCTTCAGCGATGCGGTAAAAACCATCCC
ACTGTTGGGGGAAGACCGAAATGACACTGAGTATCGCAGGGCACTTGCGCTAGTGGAGTATCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTAAATATGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACACCCTCTGGCGTTTCAGTATTGCGTACGCTCATGGACCAATACAGTCTCAAAGCAGCAGACCT
TGCCAACGAACTCGGTTCAAAATCGAACGTCAGCAACATCTTAAATGGTCGCAGAGCACTGACTGTAAGCCATATTAAAG
CGCTTGCAGAACGCTTTAATCTTCCGGCAGACGCATTCATCGAGTAG
ATGAGAACGCATCGTCATATGGATGCAGCCAGCGCAAAAAAGATTGTTGATACCTTCAGCGATGCGGTAAAAACCATCCC
ACTGTTGGGGGAAGACCGAAATGACACTGAGTATCGCAGGGCACTTGCGCTAGTGGAGTATCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTAAATATGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACACCCTCTGGCGTTTCAGTATTGCGTACGCTCATGGACCAATACAGTCTCAAAGCAGCAGACCT
TGCCAACGAACTCGGTTCAAAATCGAACGTCAGCAACATCTTAAATGGTCGCAGAGCACTGACTGTAAGCCATATTAAAG
CGCTTGCAGAACGCTTTAATCTTCCGGCAGACGCATTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|