Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5049934..5050450 Replicon chromosome
Accession NZ_CP068015
Organism Klebsiella pneumoniae strain 2016_49

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag JKF56_RS24555 Protein ID WP_004178374.1
Coordinates 5049934..5050218 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JKF56_RS24560 Protein ID WP_002886901.1
Coordinates 5050208..5050450 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKF56_RS24530 (5045330) 5045330..5045593 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
JKF56_RS24535 (5045723) 5045723..5045896 + 174 WP_041169004.1 hypothetical protein -
JKF56_RS24540 (5045899) 5045899..5046642 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JKF56_RS24545 (5046999) 5046999..5049137 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JKF56_RS24550 (5049466) 5049466..5049930 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JKF56_RS24555 (5049934) 5049934..5050218 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JKF56_RS24560 (5050208) 5050208..5050450 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JKF56_RS24565 (5050528) 5050528..5052438 - 1911 WP_012737231.1 PRD domain-containing protein -
JKF56_RS24570 (5052461) 5052461..5053615 - 1155 WP_012737230.1 lactonase family protein -
JKF56_RS24575 (5053682) 5053682..5054422 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T186430 WP_004178374.1 NZ_CP068015:c5050218-5049934 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T186430 NZ_CP089437:4795648-4795926 [Citrobacter portucalensis]
ATGAATAAACTTACTCACTACGATCCCGCGACTGCGCTGGTTGATGATGAAGAAATTGCCGTGTTTATGGCCGATGCCCT
CGAAACAGGCGATGCAGCATACATTGCAAAAGCACTGGGCGTGGTAGCTCGCGCTAAGGGAATGGCGAACATTGCGGCAG
AAACGGGATTATCCCGCGAGCAGCTTTATCGCTCTTTTAGTGAGAAAGGTAACCCGACGCTGAAAACCACCCTTGCAGTG
ATGAAGGTACTCGGCATTGAATTGACACTTAAAAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT186430 WP_002886901.1 NZ_CP068015:c5050450-5050208 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT186430 NZ_CP089437:4795338-4795655 [Citrobacter portucalensis]
ATCATGGAAATTCTTCAGACAATGGTTTTCCGGCGTTGGGAGCAAAACCTACGGGACAGGAGAGCTAAAACGCTCATTGC
CACACGCCTTTTTCGTCTGGCTAATGGTTTAGCTGGTGATGTTAAACCTGTTGGGGAAGGCGTCAGCGAAATGCGCATTT
CTTACGGTCCTGGCTACAGGATTTACTTTAAACAGCAAGGTTGCCGCATCATCATTTTGTTATGTGGGGGCGATAAAAGC
TCACAAGCCAACGATATTACTCTTGCAAAAATGCTCGCCCGTACACTGGATTCACAGGAGATCTTCTGCCATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References