Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 800467..801124 Replicon chromosome
Accession NZ_CP068015
Organism Klebsiella pneumoniae strain 2016_49

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JKF56_RS03970 Protein ID WP_002916310.1
Coordinates 800714..801124 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JKF56_RS03965 Protein ID WP_002916312.1
Coordinates 800467..800733 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKF56_RS03940 (795669) 795669..797102 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JKF56_RS03945 (797221) 797221..797949 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
JKF56_RS03950 (797999) 797999..798316 + 318 WP_077274463.1 N(4)-acetylcytidine aminohydrolase -
JKF56_RS03955 (798480) 798480..799139 + 660 WP_002916317.1 hemolysin III family protein -
JKF56_RS03960 (799238) 799238..800221 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
JKF56_RS03965 (800467) 800467..800733 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JKF56_RS03970 (800714) 800714..801124 + 411 WP_002916310.1 protein YgfX Toxin
JKF56_RS03975 (801131) 801131..801652 - 522 WP_002916308.1 flavodoxin FldB -
JKF56_RS03980 (801753) 801753..802649 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JKF56_RS03985 (802672) 802672..803385 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JKF56_RS03990 (803391) 803391..805124 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T186418 WP_002916310.1 NZ_CP068015:800714-801124 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T186418 NZ_CP089428:c228201-227719 [Klebsiella pneumoniae]
ATGGGAATGAGACCACCGGAACCACTCACCCCTGAACACAATATTGCTGAATTTTGTTGCCAGGATCAGGTTATTAATGA
GTGGCTGAAGAAGAAGGCGTTGAGAAACCACGGTACGGGAATATCGAGGGTATTCGTTGTCTGTTCTGAAAACTCAAAAA
GGGTAATTGCGTACTACTGCCTGTCATCCGGAAGCGTGCACAGAAACACTGTAACTGGAACCTACCGTCGTAATGCACCT
GCGGCAATACCGGTCATTGTTCTGGGAAGGCTGGCAGTTGATGCTGCCTGGGCAGGAAAGGGGATCGGAGCTGCACTGCT
TAAAGATGCAATATACCGGACGGAACATATCGCAGTTCAGGTCGGTGTAAGGGCGCTTCTCGTTCATGCCTTAAATGACG
AAGTCGTGGCGTTTTACACAAAGTTTGGATTCGAGACCTCTGCAGTCAATGCACTGACATTATTGTTCCCGGTCAAAGTA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT186418 WP_002916312.1 NZ_CP068015:800467-800733 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT186418 NZ_CP089428:c228470-228192 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAGGCCCCGATAAACATCCGGGCGAAAACCTCCCAGCGCGATCTTATCGACATGGCCGCAAA
TCTTGTCTCTAAATCCCGTACTGATTTTATGCTGGAAGCGGCCTGCCGTGAAGCCCAGGACATCCTGTTAGACCAGCGCT
TGTTTCTGCTGGATGATAAGCAGTTTGATACTTTTATCGAAGAGCTTGACGCTCCTGTAACCCCTGAGCGCCAGGCCCGT
ATCGATAACCTGATGAACCGAAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References