Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1806212..1807043 Replicon chromosome
Accession NZ_CP067994
Organism Escherichia coli strain CV601

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JJT18_RS08545 Protein ID WP_000854814.1
Coordinates 1806212..1806586 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag JJT18_RS08550 Protein ID WP_001285584.1
Coordinates 1806675..1807043 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJT18_RS08505 1801608..1802774 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JJT18_RS08510 1802893..1803366 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
JJT18_RS08515 1803564..1804622 + 1059 WP_001200891.1 FUSC family protein -
JJT18_RS08520 1804794..1805123 + 330 WP_000450409.1 DUF496 family protein -
JJT18_RS08525 1805224..1805406 - 183 WP_001016348.1 hypothetical protein -
JJT18_RS08530 1805478..1805606 + 129 Protein_1665 transposase domain-containing protein -
JJT18_RS08535 1805895..1806008 - 114 WP_001161660.1 DUF957 domain-containing protein -
JJT18_RS08540 1806021..1806215 - 195 WP_000988600.1 hypothetical protein -
JJT18_RS08545 1806212..1806586 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JJT18_RS08550 1806675..1807043 - 369 WP_001285584.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JJT18_RS08555 1807117..1807338 - 222 WP_000692323.1 DUF987 domain-containing protein -
JJT18_RS08560 1807401..1807847 - 447 WP_000187523.1 RadC family protein -
JJT18_RS08565 1807844..1809376 - 1533 WP_001350525.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T186392 WP_000854814.1 NZ_CP067994:c1806586-1806212 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T186392 NZ_CP089408:c108977-108693 [Klebsiella michiganensis]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAACTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATATCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT186392 WP_001285584.1 NZ_CP067994:c1807043-1806675 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT186392 NZ_CP089408:c109215-108967 [Klebsiella michiganensis]
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References