Detailed information of TA system TA186381

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 259354..260002
• Replicon: chromosome
• Accession: NZ_CP067993
• Organism: Stenotrophomonas maltophilia strain DHHJ

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A0L8AET4
• Locus tag: JJL50_RS01140
• Protein ID: WP_010486984.1
• Coordinates: 259354..259641 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: JJL50_RS01145
• Protein ID: WP_049431463.1
• Coordinates: 259700..260002 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJL50_RS01110	254576..255307	+	732	WP_032956260.1	type III pantothenate kinase	-
JJL50_RS01115	255317..256153	+	837	WP_201117864.1	SPOR domain-containing protein	-
JJL50_RS01125	256397..257248	-	852	WP_201117865.1	hypothetical protein	-
JJL50_RS01130	257369..258493	-	1125	WP_201117866.1	hypothetical protein	-
JJL50_RS01135	258521..259120	-	600	WP_201117867.1	hypothetical protein	-
JJL50_RS01140	259354..259641	+	288	WP_010486984.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JJL50_RS01145	259700..260002	+	303	WP_049431463.1	putative addiction module antidote protein	Antitoxin
JJL50_RS01150	260060..260383	-	324	WP_201117868.1	hypothetical protein	-
JJL50_RS01155	260464..260871	-	408	WP_201117869.1	hypothetical protein	-
JJL50_RS01160	261453..262397	+	945	WP_201117871.1	ankyrin repeat domain-containing protein	-
JJL50_RS01165	262415..262762	-	348	WP_201117873.1	hypothetical protein	-
JJL50_RS01170	262895..263815	+	921	WP_004137058.1	arginase	-
JJL50_RS01175	263978..264115	+	138	WP_008266021.1	entericidin A/B family lipoprotein	-
JJL50_RS01180	264319..264540	+	222	WP_019661831.1	CsbD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-90)

Antitoxin

• Uncharacterized protein HI1420 (6-99)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10744.34 Da
• Isoelectric Point: 10.8940

>T186381 WP_010486984.1 NZ_CP067993:259354-259641 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLADGVSELRIDAGPGYRVYYTQRGRQLVILLVGGDKGS
QQRDIEKAREIARAL

Nucleotide

• Length: 288 bp

>T186381 NZ_CP089404:108147-108617 [Klebsiella pasteurii]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAAACGTTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCACAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACACATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10778.38 Da
• Isoelectric Point: 8.0359

>AT186381 WP_049431463.1 NZ_CP067993:259700-260002 [Stenotrophomonas maltophilia]
MAIKRKVELKSFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAV

Nucleotide

• Length: 303 bp

>AT186381 NZ_CP089404:107707-108150 [Klebsiella pasteurii]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTGCTGGGTCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AAAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGACTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A0L8AET4