Detailed information of TA system TA186380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 103621..105204
• Replicon: chromosome
• Accession: NZ_CP067993
• Organism: Stenotrophomonas maltophilia strain DHHJ

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JJL50_RS00430
• Protein ID: WP_201117785.1
• Coordinates: 103621..104943 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: M5CTC8
• Locus tag: JJL50_RS00435
• Protein ID: WP_004134030.1
• Coordinates: 104947..105204 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJL50_RS00415	98971..100605	-	1635	WP_032128710.1	TldD/PmbA family protein	-
JJL50_RS00420	100636..102267	-	1632	WP_201117783.1	TldD/PmbA family protein	-
JJL50_RS00425	103006..103620	+	615	WP_201119267.1	DUF938 domain-containing protein	-
JJL50_RS00430	103621..104943	-	1323	WP_201117785.1	type II toxin-antitoxin system HipA family toxin	Toxin
JJL50_RS00435	104947..105204	-	258	WP_004134030.1	helix-turn-helix transcriptional regulator	Antitoxin
JJL50_RS00440	105362..109048	-	3687	WP_201117787.1	indolepyruvate ferredoxin oxidoreductase family protein	-
JJL50_RS00445	109217..109852	+	636	WP_032128715.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (152-400)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 48810.57 Da
• Isoelectric Point: 6.8740

>T186380 WP_201117785.1 NZ_CP067993:c104943-103621 [Stenotrophomonas maltophilia]
MGTLRVWMNGVEVALWDDVRSGSSRLSYVDSWISSAQSRPLSLSLPLLPEGESHRGDVVNNYFDNLLPDNAVIRNRIRDR
FSTRSSDTFDLLEAIGRDCVGAVQLLPLSHTPGNIQQITCEALDESGVAAILRQVTAGNLPGAPTSDDAFRISIAGAQEK
TGLLLHAGQWCIPTGSTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMQLLSAFGIPVANTQMGRFKDERALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVTIMDLLRQSEHFEDRATFFKTQILFWMLAATDGHAKNFSVYLE
AGGRFRLTPVYDVLSVHPILGRGPNQLDPRNAQLAMSVQGKNRHRKLHLVRRRHWNETARACGVADGAEPWIEALIAAVE
PAIEQVTRQLPSDFPVNVSEPIFNGLRAAAARLSSMSPDA

Nucleotide

• Length: 1323 bp

>T186380 NZ_CP067993:c104943-103621 [Stenotrophomonas maltophilia]
ATGGGTACGCTGCGGGTCTGGATGAATGGTGTCGAGGTCGCGCTCTGGGATGATGTCCGGAGCGGCTCTTCCCGGCTTTC
GTACGTCGACTCGTGGATCAGCTCCGCCCAGTCCCGGCCGTTGTCACTCTCACTGCCCCTGCTCCCGGAGGGTGAGAGCC
ATCGGGGCGATGTCGTCAACAACTACTTCGACAACCTTCTTCCCGACAACGCCGTCATCCGCAACCGGATCCGCGACAGG
TTCTCCACGCGCAGCAGCGACACATTCGATCTTCTCGAAGCCATTGGCCGGGATTGCGTCGGCGCAGTGCAACTGCTGCC
GCTTTCGCATACACCGGGGAACATCCAGCAGATTACGTGCGAAGCGTTGGACGAATCAGGCGTCGCTGCGATCCTGCGTC
AGGTGACGGCAGGGAATCTACCTGGCGCACCCACCAGTGATGATGCGTTCCGCATATCCATCGCCGGTGCGCAGGAGAAG
ACGGGACTTCTGCTGCATGCTGGCCAGTGGTGCATTCCTACCGGCAGTACCCCATCCACCCATATCTTCAAGCTGCCGCT
TGGCATTGTGGGCAACATGCGGGCGGACATGCACCAATCCGTCGAGAACGAATGGCTTTGCATGCAACTGCTTTCCGCCT
TTGGAATCCCCGTTGCGAATACGCAGATGGGACGCTTCAAGGACGAACGCGCGCTTATTGTGGAGCGATTCGACCGCCGC
CTTTCTGCGGATCGCCGGTGGTGGCTGCGGCTGCCGCAGGAAGACATGTGCCAGGTCTTCGGTCTGCCCGCTGCCAGGAA
GTATGAATCCGATGGCGGCCCAGGCATCGTGACCATCATGGATCTGCTTCGACAATCCGAGCATTTCGAGGATCGGGCGA
CCTTCTTCAAGACGCAGATTCTTTTCTGGATGTTGGCTGCAACCGATGGACATGCCAAGAACTTCAGTGTTTACCTCGAA
GCCGGTGGACGCTTCCGCCTGACACCCGTCTACGACGTATTGTCGGTGCATCCCATCCTGGGTAGGGGGCCAAACCAGCT
CGACCCGCGAAATGCACAGCTCGCCATGTCCGTCCAGGGCAAGAACCGCCACCGGAAGCTGCACCTTGTGCGACGACGCC
ATTGGAACGAAACCGCACGCGCCTGTGGTGTCGCTGATGGTGCGGAGCCGTGGATCGAAGCGCTGATCGCAGCCGTCGAA
CCCGCCATCGAGCAGGTCACGCGTCAGCTCCCAAGTGATTTCCCCGTAAACGTGTCCGAACCCATTTTCAACGGGCTGCG
CGCTGCGGCGGCACGCCTTTCCAGCATGTCGCCGGACGCCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9550.01 Da
• Isoelectric Point: 12.0740

>AT186380 WP_004134030.1 NZ_CP067993:c105204-104947 [Stenotrophomonas maltophilia]
MDRPLHTVRTPQQLAPLMRAFRRQAGLSQAQLAAQLGISRQAVGALERDPASASFERLMRVWAVLGLEVRLQQRSPPETT
STLEW

Nucleotide

• Length: 258 bp

>AT186380 NZ_CP067993:c105204-104947 [Stenotrophomonas maltophilia]
ATGGACAGGCCGCTGCACACGGTGAGGACACCTCAACAACTGGCACCGCTGATGCGTGCGTTCAGGCGCCAGGCGGGCCT
GAGCCAGGCGCAGTTGGCGGCACAGCTCGGCATAAGCCGCCAGGCAGTAGGCGCATTGGAGCGCGACCCGGCATCGGCAA
GCTTCGAACGGCTGATGCGGGTCTGGGCAGTGCTGGGTCTGGAAGTCAGATTGCAGCAGCGAAGCCCCCCGGAGACAACG
TCAACGTTGGAGTGGTGA

Structures

Antitoxin

• AlphaFold DB: M5CTC8