Detailed information of TA system TA186377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 544989..545616
• Replicon: chromosome
• Accession: NZ_CP067992
• Organism: Streptococcus mitis strain S022-V7-A3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A1E9GI90
• Locus tag: JJN14_RS02855
• Protein ID: WP_033676577.1
• Coordinates: 545266..545616 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: JJN14_RS02850
• Protein ID: WP_201058849.1
• Coordinates: 544989..545276 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJN14_RS02825	540775..541614	+	840	WP_001192119.1	carbohydrate ABC transporter permease	-
JJN14_RS02830	541786..542238	+	453	WP_201058847.1	YhcH/YjgK/YiaL family protein	-
JJN14_RS02835	542258..542902	+	645	WP_004261828.1	DUF624 domain-containing protein	-
JJN14_RS02840	543073..543990	+	918	WP_078238169.1	dihydrodipicolinate synthase family protein	-
JJN14_RS02845	544008..544892	+	885	WP_201058848.1	ROK family protein	-
JJN14_RS02850	544989..545276	+	288	WP_201058849.1	hypothetical protein	Antitoxin
JJN14_RS02855	545266..545616	+	351	WP_033676577.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JJN14_RS02860	545799..546650	-	852	WP_201058850.1	MurR/RpiR family transcriptional regulator	-
JJN14_RS02865	546840..548897	+	2058	WP_201058851.1	penicillin-binding protein PBP2B	-
JJN14_RS02870	548908..549504	+	597	WP_049487334.1	recombination mediator RecR	-
JJN14_RS02875	549821..550096	+	276	WP_201058852.1	TIGR04197 family type VII secretion effector	-
JJN14_RS02880	550100..550456	+	357	WP_201058853.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13726.84 Da
• Isoelectric Point: 9.6866

>T186377 WP_033676577.1 NZ_CP067992:545266-545616 [Streptococcus mitis]
MDYKKYRILYSPRVIDSLDKIYQYIAEEIGSVEAARRKVANIRKDINRLEIFPQAGFDADEKFGKKLDPHYQTRGLTLSK
DYIVLYTIVEDTVRLAYLLPSKSDYMKLFKTKSRYD

Nucleotide

• Length: 351 bp

>T186377 NZ_CP089403:2563402-2563659 [Klebsiella pasteurii]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACGTTCGCGATACATC
AGGCCGCGTCACCTCCGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAACAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10802.22 Da
• Isoelectric Point: 4.2298

>AT186377 WP_201058849.1 NZ_CP067992:544989-545276 [Streptococcus mitis]
MAIANSSKVVTFQANRELVNDAMEVLKEKNLSLSSALRLFLKNVAVTNEVDLLSEEELEKEYLFRQLQAEVQESYAKIEA
GNYLTDEDIVTRYGL

Nucleotide

• Length: 288 bp

>AT186377 NZ_CP089403:2563670-2564221 [Klebsiella pasteurii]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCAATGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCTCTTTGCTCAACGATGAGAGTGCCAGCCCGACGTTATCGCTGCTGGCCA
GGCATAACGGAAAGGCGGTTGGGCATATTTTATTCACCCGGGCGATGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGCGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCCATGGGAAGCCAGACGGTATTTGTTCTGGGCCACGCCACTTACTACCCCAGGCACGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGAGGCGCATAAAGCCTGCTGGATGCTACAGCGGCTTTCGTCT
CAGCCGCTGGGGCGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A1E9GI90