Detailed information of TA system TA186376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4831061..4831577
• Replicon: chromosome
• Accession: NZ_CP067966
• Organism: Klebsiella quasipneumoniae strain ARLG-8054

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JJ669_RS23315
• Protein ID: WP_080820655.1
• Coordinates: 4831061..4831345 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: JJ669_RS23320
• Protein ID: WP_023291757.1
• Coordinates: 4831335..4831577 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJ669_RS23305 (4828059)	4828059..4830197	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
JJ669_RS23310 (4830593)	4830593..4831057	+	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JJ669_RS23315 (4831061)	4831061..4831345	-	285	WP_080820655.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JJ669_RS23320 (4831335)	4831335..4831577	-	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JJ669_RS23325 (4831655)	4831655..4833565	-	1911	WP_044525201.1	PRD domain-containing protein	-
JJ669_RS23330 (4833588)	4833588..4834739	-	1152	WP_023291755.1	lactonase family protein	-
JJ669_RS23335 (4834806)	4834806..4835546	-	741	WP_017900574.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10957.79 Da
• Isoelectric Point: 10.3796

>T186376 WP_080820655.1 NZ_CP067966:c4831345-4831061 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVENPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T186376 NZ_CP089403:2057477-2057818 [Klebsiella pasteurii]
ATGAAAACTCTACCTGCAACGAATCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTGGCAGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCGTTCAGTGATGAAACGGTAATTCTGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCAAGAACAGTCCCCCTATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGACA
TCGTATTAGCGCGGCACGGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT186376 WP_023291757.1 NZ_CP067966:c4831577-4831335 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT186376 NZ_CP089403:2057115-2057456 [Klebsiella pasteurii]
ATGAAATATACTGAATTAGAGAACGATTCATTTCTAAAATGGGGACTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTGCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGACTACTGATGAAATAAATCCTCGCCAT
GCCCGCTGCGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACGTCGC
CGTTTACCCCACTCATCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86