Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4308229..4308982 Replicon chromosome
Accession NZ_CP067966
Organism Klebsiella quasipneumoniae strain ARLG-8054

Toxin (Protein)


Gene name ykfI Uniprot ID A0A483K7K1
Locus tag JJ669_RS20905 Protein ID WP_071843260.1
Coordinates 4308614..4308982 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8B4G4X8
Locus tag JJ669_RS20900 Protein ID WP_032410127.1
Coordinates 4308229..4308579 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJ669_RS20870 (4303405) 4303405..4304556 - 1152 WP_148676959.1 hypothetical protein -
JJ669_RS20875 (4304654) 4304654..4305547 + 894 WP_038423335.1 50S ribosome-binding GTPase -
JJ669_RS20880 (4305833) 4305833..4306510 + 678 WP_004129352.1 hypothetical protein -
JJ669_RS20885 (4306606) 4306606..4307427 + 822 WP_038423337.1 DUF932 domain-containing protein -
JJ669_RS20890 (4307498) 4307498..4307971 + 474 WP_032410128.1 DNA repair protein RadC -
JJ669_RS20895 (4307987) 4307987..4308208 + 222 WP_004129348.1 DUF987 domain-containing protein -
JJ669_RS20900 (4308229) 4308229..4308579 + 351 WP_032410127.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JJ669_RS20905 (4308614) 4308614..4308982 + 369 WP_071843260.1 TA system toxin CbtA family protein Toxin
JJ669_RS20910 (4309069) 4309069..4309215 + 147 WP_240247321.1 hypothetical protein -
JJ669_RS20915 (4309593) 4309593..4310153 + 561 WP_082225988.1 SLATT domain-containing protein -
JJ669_RS20920 (4310153) 4310153..4311490 + 1338 WP_082225989.1 reverse transcriptase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4275225..4311490 36265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13763.93 Da        Isoelectric Point: 8.2789

>T186375 WP_071843260.1 NZ_CP067966:4308614-4308982 [Klebsiella quasipneumoniae]
MNTLPAINQRAVQTCLSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVIKRHIEAGITLVDAVNFLVEKYELIRIDRRGF
SSQGPVPYLTVTDILHARRACGLTNSCPYREVSNIVLGRSRQ

Download         Length: 369 bp

>T186375 NZ_CP089403:c473300-472890 [Klebsiella pasteurii]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGCGCGCAGTGGTTCTCACTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTATTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATATTGCTGTCGCTGGTAGTGTTCGACTGCG
TACGCAGCCAGCGGCGGATCCACGCCCGTCAGGGTGAAATAAAGCTGCTGATCGACTCGCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACGCCGTGGGTAATCAACAGCGGCATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGTAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGCGACCTGCGCCGGCTAGTGTTACAGAAACCGA
CGCAAGAGTAG

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13014.93 Da        Isoelectric Point: 7.1865

>AT186375 WP_032410127.1 NZ_CP067966:4308229-4308579 [Klebsiella quasipneumoniae]
MSSKTLTVNDDTAEPWWGLNRNVIPCFGARLVQEGNRLYYLSDRASIIGLFNKADLLRLDQAFPVLLKQAELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSCGHVYISIYPTQR

Download         Length: 351 bp

>AT186375 NZ_CP089403:c473547-473281 [Klebsiella pasteurii]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGTCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTAAGCGATGGCGATAAGGCGTTATTCATCCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCTGAACTGCAGCGGATGGTAAAATTAATTCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483K7K1

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4G4X8

References