Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4115164..4115783 Replicon chromosome
Accession NZ_CP067966
Organism Klebsiella quasipneumoniae strain ARLG-8054

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JJ669_RS19925 Protein ID WP_002892050.1
Coordinates 4115565..4115783 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JJ669_RS19920 Protein ID WP_002892066.1
Coordinates 4115164..4115538 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJ669_RS19910 (4110319) 4110319..4111512 + 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JJ669_RS19915 (4111535) 4111535..4114681 + 3147 WP_023288644.1 multidrug efflux RND transporter permease subunit AcrB -
JJ669_RS19920 (4115164) 4115164..4115538 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JJ669_RS19925 (4115565) 4115565..4115783 + 219 WP_002892050.1 HHA domain-containing protein Toxin
JJ669_RS19930 (4115942) 4115942..4116508 + 567 WP_023288643.1 maltose O-acetyltransferase -
JJ669_RS19935 (4116480) 4116480..4116611 - 132 WP_162543094.1 hypothetical protein -
JJ669_RS19940 (4116645) 4116645..4117115 + 471 WP_064155186.1 YlaC family protein -
JJ669_RS19945 (4117084) 4117084..4118541 - 1458 WP_064155187.1 PLP-dependent aminotransferase family protein -
JJ669_RS19950 (4118642) 4118642..4119340 + 699 WP_044521289.1 GNAT family protein -
JJ669_RS19955 (4119337) 4119337..4119477 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JJ669_RS19960 (4119477) 4119477..4119740 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T186374 WP_002892050.1 NZ_CP067966:4115565-4115783 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T186374 NZ_CP089396:76411-76893 [Klebsiella michiganensis]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT186374 WP_002892066.1 NZ_CP067966:4115164-4115538 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT186374 NZ_CP089396:76157-76423 [Klebsiella michiganensis]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTAGAGATTGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References