Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3436693..3437172 Replicon chromosome
Accession NZ_CP067426
Organism Escherichia coli O22:H8 strain 154

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A234Y3J1
Locus tag JI426_RS17295 Protein ID WP_001444087.1
Coordinates 3436885..3437172 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A234Y267
Locus tag JI426_RS17290 Protein ID WP_001090455.1
Coordinates 3436693..3436881 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI426_RS17240 (3431766) 3431766..3431942 - 177 WP_000753060.1 hypothetical protein -
JI426_RS17245 (3431935) 3431935..3432117 - 183 WP_022581296.1 hypothetical protein -
JI426_RS17250 (3432265) 3432265..3432570 - 306 WP_053294093.1 DUF4406 domain-containing protein -
JI426_RS17255 (3432567) 3432567..3432848 - 282 WP_072094476.1 DNA-binding protein -
JI426_RS17260 (3432881) 3432881..3433642 - 762 WP_064506729.1 DUF1627 domain-containing protein -
JI426_RS17265 (3433672) 3433672..3434412 - 741 WP_000790459.1 ATP-binding protein -
JI426_RS17270 (3434419) 3434419..3435384 - 966 WP_000054520.1 hypothetical protein -
JI426_RS17275 (3435365) 3435365..3435886 - 522 WP_000705386.1 toxin YdaT family protein -
JI426_RS17280 (3435870) 3435870..3436148 - 279 WP_000548554.1 YdaS family helix-turn-helix protein -
JI426_RS17285 (3436265) 3436265..3436663 + 399 WP_000209117.1 helix-turn-helix domain-containing protein -
JI426_RS17290 (3436693) 3436693..3436881 + 189 WP_001090455.1 hypothetical protein Antitoxin
JI426_RS17295 (3436885) 3436885..3437172 + 288 WP_001444087.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JI426_RS17300 (3437444) 3437444..3437596 + 153 WP_000380321.1 DUF1391 family protein -
JI426_RS17305 (3437608) 3437608..3437976 + 369 WP_001365839.1 hypothetical protein -
JI426_RS17310 (3438761) 3438761..3438949 + 189 WP_000450222.1 cell division inhibition protein DicB -
JI426_RS17315 (3438946) 3438946..3439134 + 189 WP_022581374.1 DUF1482 family protein -
JI426_RS17320 (3439227) 3439227..3441629 + 2403 WP_136761401.1 exonuclease -
JI426_RS17325 (3441696) 3441696..3441947 + 252 WP_000273163.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - ompA / nueA / msbA 3433696..3582869 149173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11014.71 Da        Isoelectric Point: 6.2118

>T186348 WP_001444087.1 NZ_CP067426:3436885-3437172 [Escherichia coli O22:H8]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVATLSIE
IVSVVHARRQFPKQN

Download         Length: 288 bp

>T186348 NZ_CP089383:c4523304-4522354 [Klebsiella pneumoniae]
ATGGATGATTTGACAAAGCTATTCCCGGACGTTGCTGATGCTCTGGGCATTGAATCAGTTGCAATTGTAGAGAAAGATCA
TTACATCGTTGAGTTATTGCGATTGCTCCAGCCTCTGTCCTTTGATACACATCAGCTGGTTTTTGCCGGTGGAACAGCAT
TGTCTAAAGCGGGTATATCTTTGAACAGGATGTCGGAGGACGTGGACATTAAGCTTGTTCCTGTCACCGGCTTTTCCCTG
CAATATTCCAGAAATCAACGTAAAAATATCCGTAAAGATATTATTAAGACCATCACCGAAACGATTGTAGCTTCAGGTAT
GTTTAGCATGGATGAGGAGTACCCAAAGGTTACTCGTGATGAAAACCGCTATAATGAAATTCCGGTGCGCTACCCGCAGG
AATATGTACAAATTCCCTGTTTAAGGCCATTTATCAAACTGGAACTGATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCACTGGTAATGGACCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTTCCCTGCGCAACTATCGGCAG
CACGCAGGCTGAAAAACTGATCTCGATGATGCGCAGAACGGCTGCAAGTATGCGTGATGTGGAGCGTGCAGTGGATGAGT
CACTGGTGCGTCATATCTACGACAACTTTTGTATTGTCAGAGAAAAAGGTGCTGAGGTTCCTGTTTTGAAGCGCTTTGTG
CAGGAATGTATTGAGCAGGATATCCAACGTTACGGTGCTCAGTATCCTGAATTCTGCGAGTCGCCTGTTGAAGAACTAAA
AATGGGGTTGGAAGAACTGGCGAGCAACCCTGTTTATAAGGAACGCTATCTGCAGTTTGTTACACCAATGGTGTTCGGTG
AAAGCCACGTTTCCTGGGAAGAGGCCTATGCCTGTTTTCGCATAACGGCATTGGATGTGATTGATGCATAG

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7249.25 Da        Isoelectric Point: 8.6832

>AT186348 WP_001090455.1 NZ_CP067426:3436693-3436881 [Escherichia coli O22:H8]
MNTALSPMVSEFETIEQENSYNEWLRAKVAASLANPRPAIPHDEVERRMAERFAKMRKERSK

Download         Length: 189 bp

>AT186348 NZ_CP089383:c4523692-4523297 [Klebsiella pneumoniae]
ATGACCATAAAAGCTCGTATTCAGTCACGGCTGAAGCGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGATCAAATAGGCAGAGCACTGCGTGAGCTGATGAAGGAAGGACAGCTACTGAAAGTAGGCTATGGCGTCT
ATACCAAAGCGCGGCAAAATGCGATTACCGGTAAGCTGATGCCTGCTGCTCCCGGAGGTTCTGCTGCGGTAATGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGTCTGGCAGGAGCAACAAGTGCCTACAACAGTGGTAAATCTACCCAGATCCC
CGCGTCACTTGAAATCAAAACCTCCCCCCGTTTCAAGAGAACATTGTCAGTAGGGAGCAGCAAACTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A234Y3J1

Antitoxin

Source ID Structure
AlphaFold DB A0A234Y267

References