Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2727821..2728347 | Replicon | chromosome |
| Accession | NZ_CP067426 | ||
| Organism | Escherichia coli O22:H8 strain 154 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | JI426_RS13625 | Protein ID | WP_000323025.1 |
| Coordinates | 2728060..2728347 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | JI426_RS13620 | Protein ID | WP_000534858.1 |
| Coordinates | 2727821..2728060 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JI426_RS13595 (2725206) | 2725206..2725595 | + | 390 | WP_016230970.1 | helix-turn-helix domain-containing protein | - |
| JI426_RS13600 (2725614) | 2725614..2726297 | + | 684 | Protein_2673 | IS1202-like element ISEsa1 family transposase | - |
| JI426_RS13605 (2726370) | 2726370..2726519 | + | 150 | WP_011443592.1 | protein YdfW | - |
| JI426_RS13610 (2726956) | 2726956..2727288 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| JI426_RS13615 (2727491) | 2727491..2727796 | - | 306 | WP_001326990.1 | protein YdfV | - |
| JI426_RS13620 (2727821) | 2727821..2728060 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| JI426_RS13625 (2728060) | 2728060..2728347 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| JI426_RS13630 (2728419) | 2728419..2728574 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| JI426_RS13635 (2728791) | 2728791..2729042 | + | 252 | WP_000980994.1 | protein Rem | - |
| JI426_RS13640 (2729109) | 2729109..2729387 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| JI426_RS13645 (2729389) | 2729389..2730438 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| JI426_RS13650 (2730452) | 2730452..2731204 | + | 753 | WP_001047135.1 | antitermination protein | - |
| JI426_RS13655 (2731482) | 2731482..2731571 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| JI426_RS13660 (2731626) | 2731626..2731838 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| JI426_RS13665 (2732139) | 2732139..2732354 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| JI426_RS13670 (2732718) | 2732718..2732888 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| JI426_RS13675 (2733108) | 2733108..2733323 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | stxA / stxB | 2638690..2763773 | 125083 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T186346 WP_000323025.1 NZ_CP067426:2728060-2728347 [Escherichia coli O22:H8]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T186346 NZ_CP089383:3884508-3884726 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT186346 WP_000534858.1 NZ_CP067426:2727821-2728060 [Escherichia coli O22:H8]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT186346 NZ_CP089383:3884107-3884481 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|