Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 650519..651063 Replicon plasmid pTT6-1
Accession NZ_CP067421
Organism Skermanella sp. TT6

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IGS68_RS30860 Protein ID WP_201082078.1
Coordinates 650519..650854 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag IGS68_RS30865 Protein ID WP_201082080.1
Coordinates 650851..651063 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS68_RS30840 645718..646521 - 804 WP_201082074.1 SDR family oxidoreductase -
IGS68_RS30845 646643..647875 + 1233 WP_201082075.1 M20/M25/M40 family metallo-hydrolase -
IGS68_RS30850 647884..648627 - 744 WP_201082076.1 SDR family oxidoreductase -
IGS68_RS30855 648741..650222 + 1482 WP_201082077.1 gamma-glutamyltransferase -
IGS68_RS30860 650519..650854 - 336 WP_201082078.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IGS68_RS30865 650851..651063 - 213 WP_201082080.1 antitoxin MazE family protein Antitoxin
IGS68_RS30870 651300..651632 + 333 WP_201082083.1 hypothetical protein -
IGS68_RS30875 651791..652864 + 1074 WP_201082085.1 IS630 family transposase -
IGS68_RS30880 653208..654854 + 1647 WP_201082866.1 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase -
IGS68_RS30885 654826..655416 + 591 WP_201082087.1 bacteriochlorophyll 4-vinyl reductase -
IGS68_RS30890 655438..655773 + 336 WP_201082088.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hsiC1/vipB 1..821558 821558
- flank IS/Tn - - 651791..652864 1073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin

Antitoxin MazE-like

(6-68)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12035.94 Da        Isoelectric Point: 10.7659

>T186329 WP_201082078.1 NZ_CP067421:c650854-650519 [Skermanella sp. TT6]
VRRGDLVTIAGRIGGDYDGKPRPAVIIQSNDFPETDSVTVSLLTSIGIDAPLLRLRIDPAPANNLRQTSWLMIDKIATVR
RRNMGAVFGRLSDAELVQLNRALPVFLGIAG

Download         Length: 336 bp

>T186329 NZ_CP089325:c4642651-4642310 [Klebsiella pneumoniae]
ATGAAAACCATACCTGCAACAACTCAGCGGGCGGCGAAGTCGTGCCCGTCGCCCGTGGCTTTCTGGCAGATGCCACTTAC
CCGTCTGCTGGAGCAGCATTATGGCCTCACCCTGAATGACACGCCGTTCAGCGATGAAACCGCTATTCAGGAACATATCA
ACGCAGGCATCACACTGGTTGATGCCGTTAATTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AACTGTCAGGAGCAGTCCCCTTATCTGGGTGCAGTGGATATTTTGCGGGCGCGGCAGGTAACCGGCCTGTTGCGGCAAAG
CCCTCATCCTTCGATACGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8062.15 Da        Isoelectric Point: 11.2212

>AT186329 WP_201082080.1 NZ_CP067421:c651063-650851 [Skermanella sp. TT6]
MPSTVRHRVRTHRAQLRAQGLRPIQIWVPDVRSPTFKEEARRQSRAVAAAPDKADTMDFLEDIQDLGDRP

Download         Length: 213 bp

>AT186329 NZ_CP089325:c4643002-4642676 [Klebsiella pneumoniae]
ATGCCACTGACTGATGCCATACAGTGGGGATTAAAGCGAAGTTTCACACCGAATTTTGGCGCAAGGCTGGTACAGGAAGG
CAACCGACTGCACTACCTGGCTGACCGGGCCAATATCACCGGTAAATTTGTTGATGCCGAATGTCAGAAGCTGGAAGAAG
CATTCCCGCATTTTATCCGCCAGATGGAACTGATGCTGAGCACTGGCGAACTTAATCCCCGTCATGCGCACAGCGTCACT
CTCTACCACAACGCTTTCACCTGTGAAGCCGATACTCTCGGCAGTTGTGGTTACGTCTACATCGTTATTTATCCCACTCA
ACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References