Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1824392..1824963 Replicon chromosome
Accession NZ_CP067420
Organism Skermanella sp. TT6

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IGS68_RS08535 Protein ID WP_201078939.1
Coordinates 1824628..1824963 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag IGS68_RS08530 Protein ID WP_201078937.1
Coordinates 1824392..1824628 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS68_RS08505 1820039..1820428 + 390 WP_201078928.1 transposase -
IGS68_RS08510 1820425..1820778 + 354 WP_201078931.1 IS66 family insertion sequence element accessory protein TnpB -
IGS68_RS08515 1820836..1821270 + 435 WP_201078933.1 transposase -
IGS68_RS08520 1821383..1822987 + 1605 WP_201070890.1 ISL3 family transposase -
IGS68_RS08525 1823025..1824233 + 1209 WP_201078935.1 IS66 family transposase -
IGS68_RS08530 1824392..1824628 + 237 WP_201078937.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IGS68_RS08535 1824628..1824963 + 336 WP_201078939.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IGS68_RS08540 1825011..1825520 - 510 WP_201078941.1 nuclear transport factor 2 family protein -
IGS68_RS08545 1825560..1826651 - 1092 WP_201078943.1 aldo/keto reductase -
IGS68_RS08550 1826752..1827645 + 894 WP_201078945.1 LysR family transcriptional regulator -
IGS68_RS08555 1827674..1828648 - 975 WP_201078947.1 2-hydroxyacid dehydrogenase -
IGS68_RS08560 1828734..1829492 - 759 WP_201078949.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-106)

Antitoxin

Antitoxin PemI-like

(1-76)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12120.07 Da        Isoelectric Point: 9.8519

>T186324 WP_201078939.1 NZ_CP067420:1824628-1824963 [Skermanella sp. TT6]
MAAPNRGDLVWIDFTPNAGHEQAGRRPALVLSPREYHQRTSFVIVCPVTGTIKGYPFEVVLPGGLPISGAILADQVKSID
RHARRIEFAAKVPDRIVQEVQARIAPLLGLT

Download         Length: 336 bp

>T186324 NZ_CP089325:840873-841283 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8463.65 Da        Isoelectric Point: 4.2837

>AT186324 WP_201078937.1 NZ_CP067420:1824392-1824628 [Skermanella sp. TT6]
MRTEVSRWGNSLAVRLPKQVLEQAGLSEGAAVELVVEAGTVILHPAKPRYDLEELIAGITPENLPESFDDAPVGRELL

Download         Length: 237 bp

>AT186324 NZ_CP089325:840626-840892 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTATGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References