Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 778931..779502 Replicon chromosome
Accession NZ_CP067420
Organism Skermanella sp. TT6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IGS68_RS03630 Protein ID WP_201077391.1
Coordinates 779248..779502 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IGS68_RS03625 Protein ID WP_201081052.1
Coordinates 778931..779248 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS68_RS03595 774324..774593 + 270 WP_201077384.1 SHOCT domain-containing protein -
IGS68_RS03600 774909..775688 + 780 WP_201077385.1 septum site-determining protein MinC -
IGS68_RS03605 775742..776557 + 816 WP_201077387.1 septum site-determining protein MinD -
IGS68_RS03610 776554..776865 + 312 WP_201077388.1 cell division topological specificity factor MinE -
IGS68_RS03615 776963..777817 - 855 WP_201077389.1 pantoate--beta-alanine ligase -
IGS68_RS03620 777810..778652 - 843 WP_201077390.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -
IGS68_RS03625 778931..779248 - 318 WP_201081052.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IGS68_RS03630 779248..779502 - 255 WP_201077391.1 type II toxin-antitoxin system HicA family toxin Toxin
IGS68_RS03635 779675..781042 + 1368 WP_201077392.1 CRTAC1 family protein -
IGS68_RS03640 781133..782131 + 999 WP_201077394.1 DUF1611 domain-containing protein -
IGS68_RS03645 782136..783137 + 1002 WP_201077395.1 dipeptide epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9144.52 Da        Isoelectric Point: 11.4778

>T186322 WP_201077391.1 NZ_CP067420:c779502-779248 [Skermanella sp. TT6]
MNNAHRKTLASIFDRPTRADIRWTAIEAPVLALGGKVVERAGSRVLFEVSGITAIFHRPHPQPTTKKGAVDAVRQFLSNA
GVEP

Download         Length: 255 bp

>T186322 NZ_CP089325:369729-370076 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11376.72 Da        Isoelectric Point: 4.5355

>AT186322 WP_201081052.1 NZ_CP067420:c779248-778931 [Skermanella sp. TT6]
MEYKGYVSGPIDFDPEDGTFSGTVAGLADVIHFEGSNSEELVQSFRGSIDDYLAYCEEVGKTPDKPFSGKMLIRATPEIH
RKAAMRAQAEGKSLSAWVADTIKAA

Download         Length: 318 bp

>AT186322 NZ_CP089325:370076-370375 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References