Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 230..798 Replicon plasmid pE31B
Accession NZ_CP067419
Organism Aeromonas media strain E31

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag JJL53_RS24665 Protein ID WP_101617266.1
Coordinates 230..523 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JJL53_RS24670 Protein ID WP_101617265.1
Coordinates 511..798 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJL53_RS24665 230..523 - 294 WP_101617266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJL53_RS24670 511..798 - 288 WP_101617265.1 CopG family ribbon-helix-helix protein Antitoxin
JJL53_RS24675 1003..1632 + 630 WP_042044880.1 AAA family ATPase -
JJL53_RS24680 1653..1850 + 198 WP_161508007.1 chromosome partitioning protein ParB -
JJL53_RS24685 2688..2930 - 243 WP_103859311.1 plasmid replication protein RepB -
JJL53_RS24690 3001..3351 - 351 WP_201035623.1 hypothetical protein -
JJL53_RS24695 3577..3828 + 252 WP_041206019.1 DUF4160 domain-containing protein -
JJL53_RS24700 3812..4234 + 423 WP_041206020.1 DUF2442 domain-containing protein -
JJL53_RS24705 4394..5359 + 966 WP_201035624.1 replication initiation protein -
JJL53_RS24710 5536..5778 - 243 WP_134997961.1 plasmid replication protein RepB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..15349 15349


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10980.79 Da        Isoelectric Point: 10.6871

>T186321 WP_101617266.1 NZ_CP067419:c523-230 [Aeromonas media]
MPPVIFAPAALRDLQRLREFLRPKSPQVAQRAATTIQLSLRQLAAQPSMGRPIEGLPEAFREWVIPFGDSGYLARYRIEP
DVIVVLAVRHQREVGYS

Download         Length: 294 bp

>T186321 NZ_CP089325:343382-343750 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTATTAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11047.15 Da        Isoelectric Point: 4.7091

>AT186321 WP_101617265.1 NZ_CP067419:c798-511 [Aeromonas media]
MPTQSKPVSIKLDADTQERIKRLATSRERSAHWLMREAISQYVEREELRETFHRDTLEAWQEFQETGQYATAQDVDQWLA
SWGTDAEGAPPACHQ

Download         Length: 288 bp

>AT186321 NZ_CP089325:343164-343385 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References