186316

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 860792..861331 Replicon chromosome
Accession NZ_CP067416
Organism Mammaliicoccus sciuri strain TET2

Toxin (Protein)


Gene name mazF Uniprot ID A0A418JBZ2
Locus tag JJL48_RS04180 Protein ID WP_048540867.1
Coordinates 860960..861331 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A657XHG2
Locus tag JJL48_RS04175 Protein ID WP_025904510.1
Coordinates 860792..860959 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJL48_RS04150 856674..857153 + 480 WP_058612364.1 PH domain-containing protein -
JJL48_RS04155 857143..858663 + 1521 WP_201101638.1 PH domain-containing protein -
JJL48_RS04160 858653..859117 + 465 WP_058612362.1 PH domain-containing protein -
JJL48_RS04165 859149..859511 + 363 WP_058591084.1 holo-ACP synthase -
JJL48_RS04170 859559..860707 + 1149 WP_070369140.1 alanine racemase -
JJL48_RS04175 860792..860959 + 168 WP_025904510.1 hypothetical protein Antitoxin
JJL48_RS04180 860960..861331 + 372 WP_048540867.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JJL48_RS04185 861428..862432 + 1005 WP_048540866.1 PP2C family protein-serine/threonine phosphatase -
JJL48_RS04190 862537..862860 + 324 WP_025904513.1 anti-sigma factor antagonist -
JJL48_RS04195 862865..863341 + 477 WP_025904514.1 anti-sigma B factor RsbW -
JJL48_RS04200 863316..864086 + 771 WP_037589755.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13653.83 Da        Isoelectric Point: 9.9193

>T186316 WP_048540867.1 NZ_CP067416:860960-861331 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDIAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T186316 NZ_CP089317:3864988-3865374 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6136.65 Da        Isoelectric Point: 4.0121

>AT186316 WP_025904510.1 NZ_CP067416:860792-860959 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE

Download         Length: 168 bp

>AT186316 NZ_CP089317:3865367-3865687 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A418JBZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A657XHG2

References