Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4658568..4659147 Replicon chromosome
Accession NZ_CP067413
Organism Raoultella ornithinolytica strain TET32

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag JJL43_RS21750 Protein ID WP_004857517.1
Coordinates 4658860..4659147 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag JJL43_RS21745 Protein ID WP_071359132.1
Coordinates 4658568..4658873 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJL43_RS21720 4653775..4654839 - 1065 WP_004857527.1 DUF2955 domain-containing protein -
JJL43_RS21725 4654829..4655896 - 1068 WP_004857525.1 HlyD family secretion protein -
JJL43_RS21730 4655903..4656367 - 465 WP_004857523.1 MarR family transcriptional regulator -
JJL43_RS21735 4656658..4656822 - 165 WP_004857521.1 DUF1127 domain-containing protein -
JJL43_RS21740 4657000..4658412 + 1413 WP_015585221.1 PLP-dependent aminotransferase family protein -
JJL43_RS21745 4658568..4658873 - 306 WP_071359132.1 BrnA antitoxin family protein Antitoxin
JJL43_RS21750 4658860..4659147 - 288 WP_004857517.1 BrnT family toxin Toxin
JJL43_RS21755 4659264..4659683 - 420 WP_015585224.1 FosA family fosfomycin resistance glutathione transferase -
JJL43_RS21760 4659677..4660585 - 909 WP_004857513.1 LysR family transcriptional regulator -
JJL43_RS21765 4660673..4661455 + 783 WP_048024655.1 NAD(P)H-dependent oxidoreductase -
JJL43_RS21770 4661603..4662181 + 579 WP_004857495.1 TetR/AcrR family transcriptional regulator -
JJL43_RS21775 4662325..4663137 + 813 WP_004857492.1 winged helix-turn-helix domain-containing protein -
JJL43_RS21780 4663134..4663652 + 519 WP_015585229.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(35-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11106.56 Da        Isoelectric Point: 7.4684

>T186315 WP_004857517.1 NZ_CP067413:c4659147-4658860 [Raoultella ornithinolytica]
MPMEFEWDANKAASNLRKHGIRFEEAVLVFDDPQHLSRQDRYENGEYRWQTIGLVHGIIVILVAHSVRFESGAEVIRIIS
ARKADKKERSRYEHG

Download         Length: 288 bp

>T186315 NZ_CP089317:3738693-3738971 [Proteus mirabilis]
ATGGAGATATTCTGGACCATACTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTATATTGCGGAGCAGAACCTGATGGC
TGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11681.22 Da        Isoelectric Point: 9.4429

>AT186315 WP_071359132.1 NZ_CP067413:c4658873-4658568 [Raoultella ornithinolytica]
MSMVKHKRDNPTALTAQREDELKALAKKSDDDIDYSDIPSSDDEPWSEAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKKS

Download         Length: 306 bp

>AT186315 NZ_CP089317:3738424-3738693 [Proteus mirabilis]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACTTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAACGCGGCGATGTGCTTCCCCATGATATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATAAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References