Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2395872..2396785 Replicon chromosome
Accession NZ_CP067413
Organism Raoultella ornithinolytica strain TET32

Toxin (Protein)


Gene name - Uniprot ID A0A808Y4A8
Locus tag JJL43_RS11140 Protein ID WP_015584188.1
Coordinates 2395872..2396345 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A808Y7A4
Locus tag JJL43_RS11145 Protein ID WP_004862777.1
Coordinates 2396342..2396785 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJL43_RS11115 2391911..2392519 - 609 WP_201165754.1 glutathione S-transferase -
JJL43_RS11120 2392761..2393666 + 906 WP_004862790.1 transcriptional regulator GcvA -
JJL43_RS11125 2393694..2394599 - 906 WP_201165755.1 LysR family transcriptional regulator -
JJL43_RS11130 2394702..2395019 + 318 WP_004862785.1 nuclear transport factor 2 family protein -
JJL43_RS11135 2395012..2395791 + 780 WP_004862782.1 SDR family oxidoreductase -
JJL43_RS11140 2395872..2396345 - 474 WP_015584188.1 RES domain-containing protein Toxin
JJL43_RS11145 2396342..2396785 - 444 WP_004862777.1 DUF2384 domain-containing protein Antitoxin
JJL43_RS11150 2396975..2397541 - 567 WP_015584190.1 DJ-1/PfpI family protein -
JJL43_RS11155 2397939..2398721 + 783 WP_032717546.1 DUF3750 domain-containing protein -
JJL43_RS11160 2398918..2400141 + 1224 WP_004862767.1 zinc metallochaperone GTPase ZigA -
JJL43_RS11180 2401072..2401605 - 534 WP_201165762.1 acid resistance repetitive basic protein Asr -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17524.82 Da        Isoelectric Point: 4.8081

>T186312 WP_015584188.1 NZ_CP067413:c2396345-2395872 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Download         Length: 474 bp

>T186312 NZ_CP089317:c1524119-1523934 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16190.45 Da        Isoelectric Point: 4.9405

>AT186312 WP_004862777.1 NZ_CP067413:c2396785-2396342 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSILDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Download         Length: 444 bp

>AT186312 NZ_CP089317:c1523887-1523474 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808Y4A8

Antitoxin

Source ID Structure
AlphaFold DB A0A808Y7A4

References