Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 850663..851320 Replicon chromosome
Accession NZ_CP067413
Organism Raoultella ornithinolytica strain TET32

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag JJL43_RS04110 Protein ID WP_004867355.1
Coordinates 850910..851320 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag JJL43_RS04105 Protein ID WP_004867358.1
Coordinates 850663..850929 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJL43_RS04080 845798..847231 - 1434 WP_004867372.1 6-phospho-beta-glucosidase -
JJL43_RS04085 847351..848079 - 729 WP_015585782.1 MurR/RpiR family transcriptional regulator -
JJL43_RS04090 848129..848440 + 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
JJL43_RS04095 848602..849261 + 660 WP_004867362.1 hemolysin III family protein -
JJL43_RS04100 849383..850366 - 984 WP_069476444.1 tRNA-modifying protein YgfZ -
JJL43_RS04105 850663..850929 + 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
JJL43_RS04110 850910..851320 + 411 WP_004867355.1 protein YgfX Toxin
JJL43_RS04115 851328..851849 - 522 WP_004867353.1 flavodoxin FldB -
JJL43_RS04120 852028..852924 + 897 WP_032718225.1 site-specific tyrosine recombinase XerD -
JJL43_RS04125 852947..853660 + 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JJL43_RS04130 853666..855399 + 1734 WP_015585785.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T186302 WP_004867355.1 NZ_CP067413:850910-851320 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T186302 NZ_CP089315:c5393439-5393050 [Klebsiella michiganensis]
ATGCAAACCAAATCACCCCCCTTCATGCGGGCGGCATCGTCACGTCCGTCTCCCGTGGGCGTCTGGCAGACCCTGCTGAC
CTGCCTGCTGGAACACCACTATGGCCTTACGCTTAACGATACGCCGTTCAGTGATGAACTGGTGATTCAGCAACATATCG
AGGCGGGTATCTCGCTGGCCGATGCCCTGAATTTTATTGTTGAAAAGTATGAACTGGTCCGCACTGACCGGCCAGGCTTC
AGCATCAGGGAGCAGTCTCCGTTTATTACATCCATTGATATCCTCCGGGCCAGAAAGGCAACGGGGCTGATGAACCGTGA
CACGTATAAAGAGGTGACGGCTATTACCAGAGGGCAACATCCGCAGGTCAGTGCTCCAGGCAAGCGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT186302 WP_004867358.1 NZ_CP067413:850663-850929 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT186302 NZ_CP089315:c5393854-5393495 [Klebsiella michiganensis]
TTGTCGAAGAAAACCACGATAGCAACGCATGATATCAGCGAATCCTGGTGGGGGCTCAGACGCAGTGTCTCCGCGTGTTT
TGGTGCCCGACTGGTCCAGGAGGGAAACCGCCTGCATTACCTGGCTGACCGCGCGAATTTTAACGGACAGTTCTGCGATG
CGGATTTGCGCCATCTTGACCAGTCTTTCCCGGTATTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAAT
CCCCGTCATCAGCACTGCGTCACGCTGTATGCAAAAGGTCTGACCTGCGAGGCCGATACGCTCGGTTCGCATGGCTACGT
TTATATCGCGATTTATCCCACTCCCGTCACCACAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XTM6

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References